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Metabolic reprogramming: a new option for the treatment of spinal cord injury.
Chen, Jiangjie; Chen, Jinyang; Yu, Chao; Xia, Kaishun; Yang, Biao; Wang, Ronghao; Li, Yi; Shi, Kesi; Zhang, Yuang; Xu, Haibin; Zhang, Xuesong; Wang, Jingkai; Chen, Qixin; Liang, Chengzhen.
Afiliación
  • Chen J; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Chen J; Orthopedics Research Institute of Zhejiang University, Zhejiang University, Hangzhou, Zhejiang Province, China.
  • Yu C; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang Province, China.
  • Xia K; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang Province, China.
  • Yang B; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Wang R; Orthopedics Research Institute of Zhejiang University, Zhejiang University, Hangzhou, Zhejiang Province, China.
  • Li Y; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang Province, China.
  • Shi K; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang Province, China.
  • Zhang Y; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Xu H; Orthopedics Research Institute of Zhejiang University, Zhejiang University, Hangzhou, Zhejiang Province, China.
  • Zhang X; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang Province, China.
  • Wang J; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, Zhejiang Province, China.
  • Chen Q; Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Liang C; Orthopedics Research Institute of Zhejiang University, Zhejiang University, Hangzhou, Zhejiang Province, China.
Neural Regen Res ; 20(4): 1042-1057, 2025 Apr 01.
Article en En | MEDLINE | ID: mdl-38989936
ABSTRACT
Spinal cord injuries impose a notably economic burden on society, mainly because of the severe after-effects they cause. Despite the ongoing development of various therapies for spinal cord injuries, their effectiveness remains unsatisfactory. However, a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic reprogramming. In this review, we explore the metabolic changes that occur during spinal cord injuries, their consequences, and the therapeutic tools available for metabolic reprogramming. Normal spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic coupling. However, spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism, lipid metabolism, and mitochondrial dysfunction. These metabolic disturbances lead to corresponding pathological changes, including the failure of axonal regeneration, the accumulation of scarring, and the activation of microglia. To rescue spinal cord injury at the metabolic level, potential metabolic reprogramming approaches have emerged, including replenishing metabolic substrates, reconstituting metabolic couplings, and targeting mitochondrial therapies to alter cell fate. The available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord injury. To further advance the metabolic treatment of the spinal cord injury, future efforts should focus on a deeper understanding of neurometabolism, the development of more advanced metabolomics technologies, and the design of highly effective metabolic interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neural Regen Res Año: 2025 Tipo del documento: Article País de afiliación: China Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neural Regen Res Año: 2025 Tipo del documento: Article País de afiliación: China Pais de publicación: India