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Diffusion Tensor Imaging-Along the Perivascular-Space Index Is Associated with Disease Progression in Parkinson's Disease.
Wood, Kimberly H; Nenert, Rodolphe; Miften, Aya M; Kent, George W; Sleyster, Madison; Memon, Raima A; Joop, Allen; Pilkington, Jennifer; Memon, Adeel A; Wilson, Riis N; Catiul, Corina; Szaflarski, Jerzy; Amara, Amy W.
Afiliación
  • Wood KH; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Nenert R; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Miften AM; Department of Psychology, Samford University, Birmingham, Alabama, USA.
  • Kent GW; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Sleyster M; Department of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
  • Memon RA; Department of Psychology, Samford University, Birmingham, Alabama, USA.
  • Joop A; Department of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
  • Pilkington J; Department of Pathology, Emory University, Atlanta, Georgia, USA.
  • Memon AA; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Wilson RN; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Catiul C; Department of Neurology, West Virginia University, Morgantown, West Virginia, USA.
  • Szaflarski J; Department of Psychology, Samford University, Birmingham, Alabama, USA.
  • Amara AW; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mov Disord ; 2024 Jul 11.
Article en En | MEDLINE | ID: mdl-38988232
ABSTRACT

BACKGROUND:

The glymphatic clearance pathway is a waste clearance system that allows for removal of soluble proteins such as amyloid ß (Aß) from the brain. Higher Aß levels are associated with cognitive dysfunction in Parkinson's disease (PD). Diffusion tensor imaging-along the perivascular space (DTI-ALPS) is an imaging measure proposed to indirectly measure glymphatic function.

OBJECTIVES:

Evaluate differences in DTI-ALPS-index between PD and healthy controls (HC) and characterize relationships between this proposed measure of glymphatic clearance, cognition, and disease severity in PD.

METHODS:

PD (n = 32) and HC (n = 23) participants underwent brain imaging to assess DTI-ALPS. PD participants were classified as PD-normal cognition (PD-NC; n = 20) or PD-mild cognitive impairment (PD-MCI; n = 12) based on a Level II comprehensive cognitive assessment. A subgroup of PD participants (n = 21) returned for annual assessments for up to 4 years after baseline. Longitudinal outcomes included changes in performance on the comprehensive cognitive assessment and changes in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).

RESULTS:

PD participants had lower DTI-ALPS-index compared to HC. PD participants classified as PD-MCI had significantly lower DTI-ALPS-index compared to PD-NC. Lower DTI-ALPS-index at baseline was associated with longitudinal cognitive decline and worse longitudinal disease severity.

CONCLUSIONS:

Glymphatic clearance, as measured with DTI-ALPS, has potential to serve as a marker of longitudinal disease progression. Interventions targeting glymphatic function should be explored for potential to slow cognitive decline in PD. © 2024 International Parkinson and Movement Disorder Society.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mov Disord Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos