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Association of tumor budding and tumor infiltrating lymphocytes with clinicopathological parameters in gallbladder carcinoma.
Ahuja, Sana; Khan, Adil Aziz; Verma, Pooja; Zaheer, Sufian.
Afiliación
  • Ahuja S; Department of Pathology, Safdarjung Hospital, Vardhman Mahavir Medical College, New Delhi, India.
  • Khan AA; Department of Pathology, Safdarjung Hospital, Vardhman Mahavir Medical College, New Delhi, India.
  • Verma P; Department of Pathology, Safdarjung Hospital, Vardhman Mahavir Medical College, New Delhi, India.
  • Zaheer S; Department of Pathology, Safdarjung Hospital, Vardhman Mahavir Medical College, New Delhi, India.
Korean J Clin Oncol ; 20(1): 1-5, 2024 May.
Article en En | MEDLINE | ID: mdl-38988012
ABSTRACT

PURPOSE:

Gallbladder carcinoma (GBC) poses significant challenges in oncology due to its aggressive nature and limited treatment options. The lack of effective biomarkers for early detection and prognosis exacerbates the prognosis for GBC patients. Tumor budding (TB) and tumor infiltrating lymphocytes (TILs) have emerged as potential prognostic indicators in various cancers, reflecting tumor-host immune interactions and tumor aggressiveness. The study of TB and TILs in GBC is particularly important due to the limited literature available.

METHODS:

This retrospective observational study aimed to evaluate the association of TB and TILs with clinicopathological parameters in GBC patients. Clinicopathological data were collected from patients with histologically confirmed GBC who underwent surgical resection. The sections were evaluated for TB and TILs using standardized methods. Statistical analysis was performed to assess associations between these parameters and clinicopathological variables.

RESULTS:

Tumor stage and grade showed significant associations with TB and TILs, indicating their potential as prognostic markers. High TB correlated with advanced tumor stage and higher grade, while high TIL infiltration was associated with early tumor stage and lower grade. Additionally, TILs exhibited a significant association with lymphovascular invasion. Interestingly, an inverse association was observed between TB and TILs, highlighting the dynamic interplay between tumor aggressiveness and host immune response.

CONCLUSION:

TB and TILs hold prognostic significance in GBC, offering insights into its pathogenesis and potential therapeutic targets. Future research exploring the mechanistic underpinnings of tumor-host immune interactions in GBC is crucial for translating these findings into clinical applications and improving outcomes for patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Korean J Clin Oncol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Korean J Clin Oncol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: