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Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection.
Liu, Yu-Hui; Wu, Quan-Xin; Wang, Qing-Hua; Zhang, Qiao-Feng; Tang, Yi; Liu, Di; Wang, Jing-Juan; Liu, Xiao-Yu; Wang, Ling-Ru; Li, Li; Xu, Cheng; Zhu, Jie; Wang, Yan-Jiang.
Afiliación
  • Liu YH; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. yuhuiliu@tmmu.edu.cn.
  • Wu QX; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China. yuhuiliu@tmmu.edu.cn.
  • Wang QH; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, China. yuhuiliu@tmmu.edu.cn.
  • Zhang QF; Cadre Ward Two, General Hospital of Central Theater Command of PLA, Wuhan, China.
  • Tang Y; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Liu D; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China.
  • Wang JJ; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Liu XY; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China.
  • Wang LR; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Li L; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China.
  • Xu C; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Zhu J; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China.
  • Wang YJ; Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
Nat Aging ; 4(9): 1186-1193, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38987646
ABSTRACT
Emerging evidence suggests that neurological and other post-acute sequelae of COVID-19 can persist beyond or develop following SARS-CoV-2 infection. However, the long-term trajectories of cognitive change after a COVID-19 infection remain unclear. Here we investigated cognitive changes over a period of 2.5 years among 1,245 individuals aged 60 years or older who survived infection with the original SARS-CoV-2 strain in Wuhan, China, and 358 uninfected spouses. We show that the overall incidence of cognitive impairment among older COVID-19 survivors was 19.1% at 2.5 years after infection and hospitalization, evaluated using the Telephone Interview for Cognitive Status-40. Cognitive decline primarily manifested in individuals with severe COVID-19 during the initial year of infection, after which the rate of decline decelerated. Severe COVID-19, cognitive impairment at 6 months and hypertension were associated with long-term cognitive decline. These findings reveal the long-term cognitive trajectory of the disease and underscore the importance of post-infection cognitive care for COVID-19 survivors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrevivientes / Disfunción Cognitiva / SARS-CoV-2 / COVID-19 Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Nat Aging Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrevivientes / Disfunción Cognitiva / SARS-CoV-2 / COVID-19 Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Nat Aging Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos