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Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).
Schenk, Simon; Sagendorf, Tyler J; Many, Gina M; Lira, Ana K; de Sousa, Luis G O; Bae, Dam; Cicha, Michael; Kramer, Kyle S; Muehlbauer, Michael; Hevener, Andrea L; Rector, R Scott; Thyfault, John P; Williams, John P; Goodyear, Laurie J; Esser, Karyn A; Newgard, Christopher B; Bodine, Sue C.
Afiliación
  • Schenk S; Department of Orthopaedic Surgery, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
  • Sagendorf TJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
  • Many GM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
  • Lira AK; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  • de Sousa LGO; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  • Bae D; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
  • Cicha M; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  • Kramer KS; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  • Muehlbauer M; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  • Hevener AL; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA.
  • Rector RS; Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
  • Thyfault JP; Research Service, Harry S. Truman Memorial Veterans' Medical Center, Columbia, MO 65201, USA.
  • Williams JP; NextGen Precision Health, University of Missouri, Columbia, MO 65201, USA.
  • Goodyear LJ; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA.
  • Esser KA; Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO 65211, USA.
  • Newgard CB; Department of Cell Biology and Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
  • Bodine SC; KU Diabetes Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Function (Oxf) ; 5(4)2024 Jul 11.
Article en En | MEDLINE | ID: mdl-38984994
ABSTRACT
While regular physical activity is a cornerstone of health, wellness, and vitality, the impact of endurance exercise training on molecular signaling within and across tissues remains to be delineated. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to characterize molecular networks underlying the adaptive response to exercise. Here, we describe the endurance exercise training studies undertaken by the Preclinical Animal Sites Studies component of MoTrPAC, in which we sought to develop and implement a standardized endurance exercise protocol in a large cohort of rats. To this end, Adult (6-mo) and Aged (18-mo) female (n = 151) and male (n = 143) Fischer 344 rats were subjected to progressive treadmill training (5 d/wk, ∼70%-75% VO2max) for 1, 2, 4, or 8 wk; sedentary rats were studied as the control group. A total of 18 solid tissues, as well as blood, plasma, and feces, were collected to establish a publicly accessible biorepository and for extensive omics-based analyses by MoTrPAC. Treadmill training was highly effective, with robust improvements in skeletal muscle citrate synthase activity in as little as 1-2 wk and improvements in maximum run speed and maximal oxygen uptake by 4-8 wk. For body mass and composition, notable age- and sex-dependent responses were observed. This work in mature, treadmill-trained rats represents the most comprehensive and publicly accessible tissue biorepository, to date, and provides an unprecedented resource for studying temporal-, sex-, and age-specific responses to endurance exercise training in a preclinical rat model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Ratas Endogámicas F344 / Envejecimiento / Adaptación Fisiológica Límite: Animals Idioma: En Revista: Function (Oxf) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Ratas Endogámicas F344 / Envejecimiento / Adaptación Fisiológica Límite: Animals Idioma: En Revista: Function (Oxf) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido