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Crystal structure of the cytotoxic macrocyclic trichothecene Isororidin A.
Asmaey, Mostafa A; Kalofolias, Dimitris A; Charavgi, Maria Despoina; Abdel-Rahim, Ismail R; Chrysina, Evangelia D; Abatis, Dennis.
Afiliación
  • Asmaey MA; Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens 15771, Greece.
  • Kalofolias DA; Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece.
  • Charavgi MD; Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece.
  • Abdel-Rahim IR; Botany and Microbiology Department, Faculty of Science, Assiut University, Egypt.
  • Chrysina ED; Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece.
  • Abatis D; Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens 15771, Greece.
Acta Crystallogr C Struct Chem ; 80(Pt 8): 407-411, 2024 08 01.
Article en En | MEDLINE | ID: mdl-38984909
ABSTRACT
The highly cytotoxic macrocyclic trichothecene Isororidin A (C29H40O9) was isolated from the fungus Myrothesium verrucaria endophytic on the wild medicinal plant `Datura' (Datura stramonium L.) and was characterized by one- (1D) and two-dimensional (2D) NMR spectroscopy. The three-dimensional structure of Isororidin A has been confirmed by X-ray crystallography at 0.81 Šresolution from crystals grown in the orthorhombic space group P212121, with one molecule per asymmetric unit. Isororidin A is the epimer of previously described (by X-ray crystallography) Roridin A at position C-13' of the macrocyclic ring.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tricotecenos Idioma: En Revista: Acta Crystallogr C Struct Chem Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tricotecenos Idioma: En Revista: Acta Crystallogr C Struct Chem Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido