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SARS-CoV-2 antibody levels and long COVID occurrence in blood donors.
Avelino-Silva, Vivian I; Bruhn, Roberta; Zurita, Karla G; Deng, Xutao; Yu, Elaine A; Grebe, Eduard; Stone, Mars; Lanteri, Marion C; Spencer, Bryan R; Busch, Michael P; Custer, Brian.
Afiliación
  • Avelino-Silva VI; Vitalant Research Institute, California, San Francisco, USA.
  • Bruhn R; Department of Epidemiology and Biostatistics, University of California San Francisco, California, San Francisco, USA.
  • Zurita KG; Vitalant Research Institute, California, San Francisco, USA.
  • Deng X; Department of Laboratory Medicine, University of California San Francisco, California, San Francisco, USA.
  • Yu EA; Vitalant Research Institute, California, San Francisco, USA.
  • Grebe E; Department of Laboratory Medicine, University of California San Francisco, California, San Francisco, USA.
  • Stone M; Vitalant Research Institute, California, San Francisco, USA.
  • Lanteri MC; Department of Laboratory Medicine, University of California San Francisco, California, San Francisco, USA.
  • Spencer BR; Vitalant Research Institute, California, San Francisco, USA.
  • Busch MP; Department of Laboratory Medicine, University of California San Francisco, California, San Francisco, USA.
  • Custer B; Vitalant Research Institute, California, San Francisco, USA.
Transfusion ; 64(9): 1719-1731, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38984497
ABSTRACT

BACKGROUND:

Long COVID is a common condition lacking consensus definition; determinants remain incompletely understood. Characterizing immune profiles associated with long COVID could support the development of preventive and therapeutic strategies.

METHODS:

We used a survey to investigate blood donors' infection/vaccination history and acute/persistent symptoms following COVID-19. The prevalence of long COVID was evaluated using self-report and an adapted definition from the RECOVER study. We evaluated factors associated with long COVID, focusing on anti-spike and anti-nucleocapsid SARS-CoV-2 antibodies. Lastly, we investigated long COVID clinical subphenotypes using hierarchical clustering.

RESULTS:

Of 33,610 participants, 16,003 (48%) reported having had COVID-19; 1853 (12%) had self-reported long COVID, 685 (4%) met an adapted RECOVER definition, and 2050 (13%) met at least one definition. Higher anti-nucleocapsid levels measured 12-24 weeks post-infection were associated with higher risk of self-reported and RECOVER long COVID. Higher anti-spike IgG levels measured 12-24 weeks post-infection were associated with lower risk of self-reported long COVID. Higher total anti-spike measured 24-48 weeks post-infection was associated with lower risk of RECOVER long COVID. Cluster analysis identified four clinical subphenotypes; patterns included neurological and psychiatric for cluster 1; neurological and respiratory for cluster 2; multi-systemic for cluster 3; and neurological for cluster 4.

DISCUSSION:

Long COVID prevalence in blood donors varies depending on the adopted definition. Anti-SARS-CoV-2 antibodies were time-dependently associated with long COVID; higher anti-nucleocapsid levels were associated with higher risk; and higher anti-spike levels were associated with lower risk of long COVID. Different underlying pathophysiologic mechanisms may be associated with distinct clinical subphenotypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Sangre / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transfusion Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Donantes de Sangre / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transfusion Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos