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Nonepisodic angioedema with eosinophilia following a rose-thorn prick injury.
Matsuo, Kimitoshi; Takahashi, Hidenori; Nagamatsu, Hiroki; Hirose, Ryutaro; Yamada, Yuka; Takei, Hiroaki; Toba, Naoya; Toyama-Kousaka, Mio; Ota, Shinichiro; Morikawa, Miwa; Shinkai, Masaharu.
Afiliación
  • Matsuo K; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
  • Takahashi H; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
  • Nagamatsu H; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
  • Hirose R; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
  • Yamada Y; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
  • Takei H; Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Meguro-ku, Tokyo, Japan.
  • Toba N; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
  • Toyama-Kousaka M; Division of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Meguro-ku, Tokyo, Japan.
  • Ota S; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
  • Morikawa M; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
  • Shinkai M; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Shinagawa-ku, Tokyo, Japan.
Int J Cardiol Cardiovasc Risk Prev ; 22: 200301, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38983608
ABSTRACT

Background:

Nonepisodic angioedema with eosinophilia (NEAE) is a condition marked by angioedema and significant eosinophilia and often linked with atopic dermatitis. It predominantly affects young Asian women and occurs more frequently in the autumn and winter. Despite over 100 reported cases, its etiology and pathogenesis remain unclear. Case presentation A 23-year-old Japanese female florist presented with acute arm swelling following rose-thorn pricks to her hands and fingers in spring. One week later, she developed progressive symmetrical non-pitting edema in her lower legs and a 3 kg weight gain without any rash. She had a history of oral allergy syndrome to apples and pears for which allergen-specific IgE were previously detected. Blood tests showed significant eosinophilia (14,930 cells/µL) and elevated thymus and activation-regulated chemokine (TARC) levels (12,864 pg/mL). Thyroid disease, autoimmune disorders, and hematologic malignancies were ruled out. Normal cardiac markers and a whole-body computed tomography excluded visceral organ involvement. She was diagnosed with NEAE and treated with oral prednisolone, which resolved the edema within 10 days. Prednisolone was tapered gradually on an outpatient basis without recurrence.

Conclusion:

A review of the literature indicates that NEAE triggered by subcutaneous antigen exposure may not follow the typical age or seasonal patterns. Direct subcutaneous antigen exposure, including rose-thorn pricks, can trigger NEAE. Clinicians should consider NEAE in atypical presentations and thoroughly investigate preceding episodes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Cardiol Cardiovasc Risk Prev Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Cardiol Cardiovasc Risk Prev Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos