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Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis.
Shimizu, Kaoruko; Kimura, Hirokazu; Tanabe, Naoya; Tanimura, Kazuya; Chubachi, Shotaro; Iijima, Hiroaki; Sato, Susumu; Wakazono, Nobuyasu; Nakamaru, Yuji; Okada, Kazufumi; Makita, Hironi; Goudarzi, Houman; Suzuki, Masaru; Nishimura, Masaharu; Konno, Satoshi.
Afiliación
  • Shimizu K; Division of Emergent Respiratory and Cardiovascular Medicine, Hokkaido University Hospital, Sapporo, Japan.
  • Kimura H; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
  • Tanabe N; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
  • Tanimura K; Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Chubachi S; Department of Respiratory Medicine, Nara Medical University, Kashihara, Japan.
  • Iijima H; Department of Medicine, Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Sato S; Department of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan.
  • Wakazono N; Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Nakamaru Y; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
  • Okada K; Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hokkaido University, Sapporo, Japan.
  • Makita H; Data Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan.
  • Goudarzi H; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
  • Suzuki M; Hokkaido Medical Research Institute for Respiratory Diseases, Sapporo, Japan.
  • Nishimura M; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
  • Konno S; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
J Allergy Clin Immunol Glob ; 3(3): 100277, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38983113
ABSTRACT

Background:

Deteriorated sinusitis and increased adiposity relative to muscle mass may affect quality of life in patients with asthma. However, whether these effects are observed regardless of intrapulmonary pathology is unknown.

Objectives:

We evaluated the correlation of the cross-sectional ratio of abdominal visceral fat (VF) to erector spinae muscle (ESM) and sinus findings based on Lund-Mackey scoring system (LMS) on computed tomography (CT) with the impaired score of the Asthma Quality of Life Questionnaire (AQLQ), regardless of airway and parenchymal disease, in patients with asthma.

Methods:

We recruited participants from the Hokkaido-based severe asthma cohort who had completed AQLQ and CT examination at the entry. The participants were divided into high (highest) and low (other quartiles) groups on the bases of the extrapulmonary indices. Multivariate analysis examined the association of VF/ESM for the adiposity-to-muscle ratio and LMS with AQLQ after adjusting for the airway fractal dimension for airway index and percentage of low attenuation volume to lung volume for parenchymal index.

Results:

No significant differences were observed in VF/ESM and LMS in terms of sex. The AQLQ score in the high VF/ESM group and high LMS group was lower than those in low VF/ESM group and low LMS group (63 male and 100 female subjects). High VF/ESM (estimate [95% confidence interval] (-0.43 [-0.61, -0.25]) and high LMS scores (-0.22 [-0.41, -0.03]) were associated with low AQLQ scores when adjusted for age, body mass index, smoking status, blood eosinophil count, and intrapulmonary CT indices.

Conclusions:

Increased VF relative to ESM mass and high LMS may deteriorate asthma-related quality of life, regardless of presence of intrapulmonary disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Allergy Clin Immunol Glob Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Allergy Clin Immunol Glob Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos