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Behaviour of Tunisian Psammomys obesus fed high-calorie diets: biochemical disturbance and histopathological alterations.
Chrigui, Souhaieb; Mbarek, Sihem; Hadj Taieb, Sameh; Haouas, Zohra; Feki, Monssef; Benlarbi, Maha; Zemmel, Ayachi; Chigr, Fatiha; Boudhrioua, Nourhène; Ben Chaouacha-Chekir, Rafika.
Afiliación
  • Chrigui S; Laboratory of Physiopathology, Food and Biomolecules, LR17ES03, Higher Institute of Biotechnology Sidi Thabet, Ariana, Tunisia.
  • Mbarek S; Laboratory of Physiopathology, Food and Biomolecules, LR17ES03, Higher Institute of Biotechnology Sidi Thabet, Ariana, Tunisia.
  • Hadj Taieb S; Laboratory of Clinical Biochemistry, Rabta Hospital, LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
  • Haouas Z; Laboratory of Histology and Cytogenetic LR18ES40, Faculty of Medicineg of Monastir, University of Monastir, Monastir, Tunisia.
  • Feki M; Laboratory of Clinical Biochemistry, Rabta Hospital, LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
  • Benlarbi M; Laboratory of Physiopathology, Food and Biomolecules, LR17ES03, Higher Institute of Biotechnology Sidi Thabet, Ariana, Tunisia.
  • Zemmel A; Herbes de Tunisie, Siliana, Tunisia.
  • Chigr F; Biological Engineering Laboratory, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Beni Mellal, Morocco.
  • Boudhrioua N; Laboratory of Physiopathology, Food and Biomolecules, LR17ES03, Higher Institute of Biotechnology Sidi Thabet, Ariana, Tunisia.
  • Ben Chaouacha-Chekir R; Laboratory of Physiopathology, Food and Biomolecules, LR17ES03, Higher Institute of Biotechnology Sidi Thabet, Ariana, Tunisia.
Arch Physiol Biochem ; : 1-17, 2024 Jul 10.
Article en En | MEDLINE | ID: mdl-38982878
ABSTRACT
This work investigated the biochemical disturbances and histological alteration in Psammomys obesus animal model fed different high calorie diets (HCDs) during three months. Four diets were used a low-calorie natural diet, Chenopodiaceae halophyte plant used as control (LCD), a high standard carbohydrate diet rich in protein, HCD 0, a high carbohydrate diet rich in two concentrations of fat, HCD 1 and HCD 2. All animals having received HCDs developed dyslipidemia after one month of experiment with distinction of different sub-groups developing or not obesity and diabetes. HCDs induced a remarkable increasing in blood cholesterol, LDL-cholesterol and triglyceride levels indicating a fast induction of dyslipidemia and a significant increase of aminotransaminases activities revealing a pronounced hepatotoxicity. Animal developing diabetes showed a severe hepatic injury, a degeneration of the adipose tissue and a significant reduction of retinal thickness. P. obesus seems to be an excellent animal model to investigate nutritional metabolic diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arch Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arch Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Reino Unido