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Pre-clinical Models for Geriatric Pharmacotherapy.
Hilmer, Sarah N; Johnell, Kristina; Mach, John.
Afiliación
  • Hilmer SN; Kolling Institute, The University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia. sarah.hilmer@sydney.edu.au.
  • Johnell K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Mach J; Kolling Institute, The University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.
Drugs Aging ; 41(8): 633-640, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38982010
ABSTRACT
With ageing of the population worldwide and discovery of new medications for prevention and management of age-related conditions, there is increasing use of medications by older adults. There are international efforts to increase the representativeness of participants in clinical trials to match the intended real-world users of the medications across a range of characteristics including age, multimorbidity, polypharmacy and frailty. Currently, much of the data on medication-related harm in older adults are from pharmacovigilance studies. New methods in pre-clinical models have allowed for measurement of exposures (such as chronic exposure, polypharmacy and deprescribing) and outcomes (such as health span functional measures and frailty) that are highly relevant to geriatric pharmacotherapy. Here we describe opportunities for design and implementation of pre-clinical models that can better predict drug effects in geriatric patients. This could improve the translation of new drugs from bench to bedside and improve outcomes of pharmacotherapy in older adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Geriatría Límite: Aged / Animals / Humans Idioma: En Revista: Drugs Aging Asunto de la revista: GERIATRIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Geriatría Límite: Aged / Animals / Humans Idioma: En Revista: Drugs Aging Asunto de la revista: GERIATRIA / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Nueva Zelanda