Your browser doesn't support javascript.
loading
Generation and repair of thymic epithelial cells.
Anderson, Graham; Cosway, Emilie J; James, Kieran D; Ohigashi, Izumi; Takahama, Yousuke.
Afiliación
  • Anderson G; Institute for Immunology and Immunotherapy, University of Birmingham , Birmingham, UK.
  • Cosway EJ; Institute for Immunology and Immunotherapy, University of Birmingham , Birmingham, UK.
  • James KD; Institute for Immunology and Immunotherapy, University of Birmingham , Birmingham, UK.
  • Ohigashi I; Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima, Japan.
  • Takahama Y; Thymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA.
J Exp Med ; 221(10)2024 Oct 07.
Article en En | MEDLINE | ID: mdl-38980292
ABSTRACT
In the vertebrate immune system, thymus stromal microenvironments support the generation of αßT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function. Here, we discuss the developmental pathways that regulate thymic epithelial cell diversity during both the embryonic and postnatal periods. We also examine how thymus microenvironments respond to injury, with particular focus on mechanisms that ensure regeneration of thymic epithelial cells for the restoration of thymus function.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timo / Células Epiteliales Límite: Animals / Humans Idioma: En Revista: J Exp Med Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timo / Células Epiteliales Límite: Animals / Humans Idioma: En Revista: J Exp Med Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos