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Composite Hydrogel Sealants for Annulus Fibrosus Repair.
Li, Xuan; Huo, Ran; Li, Li; Cherif, Hosni; Lan, Xiaoyi; Weber, Michael H; Haglund, Lisbet; Li, Jianyu.
Afiliación
  • Li X; Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, Quebec H3A 0C3, Canada.
  • Huo R; Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, Quebec H3A 0C3, Canada.
  • Li L; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada.
  • Cherif H; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada.
  • Lan X; Department of Mechanical Engineering, McGill University, 817 Sherbrooke St W, Montreal, Quebec H3A 0C3, Canada.
  • Weber MH; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada.
  • Haglund L; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada.
  • Li J; Department of Surgery, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A3, Canada.
ACS Biomater Sci Eng ; 10(8): 5094-5107, 2024 Aug 12.
Article en En | MEDLINE | ID: mdl-38979636
ABSTRACT
Intervertebral disc (IVD) herniation is a leading cause of disability and lower back pain, causing enormous socioeconomic burdens. The standard of care for disc herniation is nucleotomy, which alleviates pain but does not repair the annulus fibrosus (AF) defect nor recover the biomechanical function of the disc. Existing bioadhesives for AF repair are limited by insufficient adhesion and significant mechanical and geometrical mismatch with the AF tissue, resulting in the recurrence of protrusion or detachment of bioadhesives. Here, we report a composite hydrogel sealant constructed from a composite of a three-dimensional (3D)-printed thermoplastic polyurethane (TPU) mesh and tough hydrogel. We tailored the fiber angle and volume fraction of the TPU mesh design to match the angle-ply structure and mechanical properties of native AF. Also, we proposed and tested three types of geometrical design of the composite hydrogel sealant to match the defect shape and size. Our results show that the sealant could mimic native AF in terms of the elastic modulus, flexural modulus, and fracture toughness and form strong adhesion with the human AF tissue. The bovine IVD tests show the effectiveness of the composite hydrogel sealant for AF repair and biomechanics recovery and for preventing herniation with its heightened stiffness and superior adhesion. By harnessing the combined capabilities of 3D printing and bioadhesives, these composite hydrogel sealants demonstrate promising potential for diverse applications in tissue repair and regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Anillo Fibroso Límite: Animals / Humans Idioma: En Revista: ACS Biomater Sci Eng Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Anillo Fibroso Límite: Animals / Humans Idioma: En Revista: ACS Biomater Sci Eng Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos