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Corticostriatal ensemble dynamics across heroin self-administration to reinstatement.
Clarke, Rachel E; Grant, Roger I; Woods, Shannon N; Pagoota, Bayleigh E; Buchmaier, Sophie; Bordieanu, Bogdan; Tsyrulnikov, Anna; Westphal, Annaka M; Paniccia, Jacqueline E; Doncheck, Elizabeth M; Carroll-Deaton, Jayda; Vollmer, Kelsey M; Ward, Amy L; Winston, Kion T; King, Danielle I; Baek, Jade; Martino, Mike R; Green, Lisa M; McGinty, Jacqueline F; Scofield, Michael D; Otis, James M.
Afiliación
  • Clarke RE; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Grant RI; Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Woods SN; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Pagoota BE; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Buchmaier S; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Bordieanu B; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Tsyrulnikov A; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Westphal AM; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Paniccia JE; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Doncheck EM; Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Carroll-Deaton J; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Vollmer KM; Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Ward AL; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Winston KT; Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  • King DI; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Baek J; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Martino MR; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Green LM; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • McGinty JF; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Scofield MD; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Otis JM; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
bioRxiv ; 2024 Jun 27.
Article en En | MEDLINE | ID: mdl-38979314
ABSTRACT
Corticostriatal projection neurons from prelimbic medial prefrontal cortex to the nucleus accumbens core critically regulate drug-seeking behaviors, yet the underlying encoding dynamics whereby these neurons contribute to drug seeking remain elusive. Here we use two-photon calcium imaging to visualize the activity of corticostriatal neurons in mice from the onset of heroin use to relapse. We find that the activity of these neurons is highly heterogeneous during heroin self-administration and seeking, with at least 8 distinct neuronal ensembles that display both excitatory and inhibitory encoding dynamics. These neuronal ensembles are particularly apparent during relapse, where excitatory responses are amplified compared to heroin self-administration. Moreover, we find that optogenetic inhibition of corticostriatal projection neurons attenuates heroin seeking regardless of the relapse trigger. Our results reveal the precise corticostriatal activity dynamics underlying drug-seeking behaviors and support a key role for this circuit in mediating relapse to drug seeking.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos