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Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy.
Han, Kai; Xie, Fang; Animasahun, Olamide; Nenwani, Minal; Kitamoto, Sho; Kim, Yeji; Phoo, May Thazin; Xu, Jin; Wuchu, Fulei; Omoloja, Kehinde; Achreja, Abhinav; Choppara, Srinadh; Li, Zhaoheng; Gong, Wang; Cho, Young Seok; Dobson, Hannah; Ahn, Jinsung; Zhou, Xingwu; Huang, Xuehui; An, Xinran; Kim, Alexander; Xu, Yao; Wu, Qi; Lee, Soo-Hong; O'Konek, Jessica J; Xie, Yuying; Lei, Yu Leo; Kamada, Nobuhiko; Nagrath, Deepak; Moon, James J.
Afiliación
  • Han K; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
  • Xie F; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Animasahun O; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China.
  • Nenwani M; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
  • Kitamoto S; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Kim Y; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Phoo MT; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Xu J; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Wuchu F; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Omoloja K; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Achreja A; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Choppara S; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Li Z; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
  • Gong W; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
  • Cho YS; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.
  • Dobson H; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Ahn J; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Zhou X; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Huang X; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • An X; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Kim A; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Xu Y; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Wu Q; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Lee SH; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • O'Konek JJ; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Xie Y; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Lei YL; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Kamada N; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Nagrath D; Graduate Program in Biostatistics, University of Washington, Seattle, WA, USA.
  • Moon JJ; Departments of Head and Neck Surgery and of Cancer Biology, the University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Nat Mater ; 2024 Jul 08.
Article en En | MEDLINE | ID: mdl-38977883
ABSTRACT
Despite the potential of oral immunotherapy against food allergy, adverse reactions and loss of desensitization hinder its clinical uptake. Dysbiosis of the gut microbiota is implicated in the increasing prevalence of food allergy, which will need to be regulated to enable for an effective oral immunotherapy against food allergy. Here we report an inulin gel formulated with an allergen that normalizes the dysregulated ileal microbiota and metabolites in allergic mice, establishes allergen-specific oral tolerance and achieves robust oral immunotherapy efficacy with sustained unresponsiveness in food allergy models. These positive outcomes are associated with enhanced allergen uptake by antigen-sampling dendritic cells in the small intestine, suppressed pathogenic type 2 immune responses, increased interferon-γ+ and interleukin-10+ regulatory T cell populations, and restored ileal abundances of Eggerthellaceae and Enterorhabdus in allergic mice. Overall, our findings underscore the therapeutic potential of the engineered allergen gel as a suitable microbiome-modulating platform for food allergy and other allergic diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Mater Asunto de la revista: CIENCIA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Mater Asunto de la revista: CIENCIA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido