Your browser doesn't support javascript.
loading
HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures.
Pastor-Alonso, Oier; Durá, Irene; Bernardo-Castro, Sara; Varea, Emilio; Muro-García, Teresa; Martín-Suárez, Soraya; Encinas-Pérez, Juan Manuel; Pineda, Jose Ramon.
Afiliación
  • Pastor-Alonso O; Laboratory of Neural Stem Cells and Neurogenesis, Achucarro Basque Center for Neuroscience, Bizkaia, Spain.
  • Durá I; Laboratory of Neural Stem Cells and Neurogenesis, Achucarro Basque Center for Neuroscience, Bizkaia, Spain.
  • Bernardo-Castro S; Laboratory of Neural Stem Cells and Neurogenesis, Achucarro Basque Center for Neuroscience, Bizkaia, Spain.
  • Varea E; Faculty of Biology, University of Valencia, Valencia, Spain.
  • Muro-García T; Laboratory of Neural Stem Cells and Neurogenesis, Achucarro Basque Center for Neuroscience, Bizkaia, Spain.
  • Martín-Suárez S; Laboratory of Neural Stem Cells and Neurogenesis, Achucarro Basque Center for Neuroscience, Bizkaia, Spain.
  • Encinas-Pérez JM; Laboratory of Neural Stem Cells and Neurogenesis, Achucarro Basque Center for Neuroscience, Bizkaia, Spain jm.encinas@achucarro.org.
  • Pineda JR; Ikerbasque, The Basque Foundation for Science, Bizkaia, Spain.
Life Sci Alliance ; 7(9)2024 Sep.
Article en En | MEDLINE | ID: mdl-38977310
ABSTRACT
Hippocampal seizures mimicking mesial temporal lobe epilepsy cause a profound disruption of the adult neurogenic niche in mice. Seizures provoke neural stem cells to switch to a reactive phenotype (reactive neural stem cells, React-NSCs) characterized by multibranched hypertrophic morphology, massive activation to enter mitosis, symmetric division, and final differentiation into reactive astrocytes. As a result, neurogenesis is chronically impaired. Here, using a mouse model of mesial temporal lobe epilepsy, we show that the epidermal growth factor receptor (EGFR) signaling pathway is key for the induction of React-NSCs and that its inhibition exerts a beneficial effect on the neurogenic niche. We show that during the initial days after the induction of seizures by a single intrahippocampal injection of kainic acid, a strong release of zinc and heparin-binding epidermal growth factor, both activators of the EGFR signaling pathway in neural stem cells, is produced. Administration of the EGFR inhibitor gefitinib, a chemotherapeutic in clinical phase IV, prevents the induction of React-NSCs and preserves neurogenesis.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Transducción de Señal / Neurogénesis / Células-Madre Neurales / Receptores ErbB / Factor de Crecimiento Similar a EGF de Unión a Heparina / Hipocampo Límite: Animals Idioma: En Revista: Life Sci Alliance Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Transducción de Señal / Neurogénesis / Células-Madre Neurales / Receptores ErbB / Factor de Crecimiento Similar a EGF de Unión a Heparina / Hipocampo Límite: Animals Idioma: En Revista: Life Sci Alliance Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos