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Therapeutic Potential of Brassica oleracea and Raphanus sativus Aqueous Extracts on a Prediabetic Rat Model.
Uuh Narvaez, Jonatan Jafet; Acevedo Fernández, Juan José; Negrete León, Elizabeth; Martínez Rivera, José Iván; Guillermo Cordero, José Leonardo; Segura Campos, Maira Rubi.
Afiliación
  • Uuh Narvaez JJ; Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida, México.
  • Acevedo Fernández JJ; Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, México.
  • Negrete León E; Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, México.
  • Martínez Rivera JI; Facultad de Ciencias de la Salud, Universidad Autónoma de Baja California, Mexicali, México.
  • Guillermo Cordero JL; Departamento de Medicina Preventiva y Salud Animal, Universidad Autónoma de Yucatán, Mérida, México.
  • Segura Campos MR; Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida, México.
J Med Food ; 27(7): 627-635, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38976324
ABSTRACT
Type 2 diabetes (T2D) is a serious health problem, and its prevalence is expected to increase worldwide in the years ahead. Cruciferous vegetables such as Brassica oleracea var. capitata L. (green cabbage) and Raphanus sativus L. (radish) have therapeutic properties that can be used to support the treatment of T2D. This study evaluated the effect of B. oleracea (BAE) and R. sativus (RAE) aqueous extracts on zoometric parameters, glycemic profiles, and pancreas and liver in prediabetic rats induced by a high-sucrose diet (HSD). BAE and RAE were administered to male HSD-induced Wistar rats (n = 35) at 5 and 10 mg/kg doses for 5 weeks. Zoometric and biochemical changes were measured, and then the pancreas and liver histological preparations were analyzed to observe the protective effect. BAE decreased feed intake and weight gain. Both extracts decreased fasting glucose and insulin levels compared with control (not treated), although not significantly (P > .05). The extracts significantly (P < .05) reduced homeostatic model assessment for insulin resistance, homeostasis model assessment of ß-cell function, and glucose intolerance, similar to metformin control. In addition, minor damage occurred in the pancreas and liver. The results indicated that BAE and RAE decreased weight gain, improved glucose regulation, and protected the pancreas and liver in HSD rats. Therefore, they have multiple therapeutical properties and may be helpful in the prevention of T2D.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Glucemia / Brassica / Extractos Vegetales / Ratas Wistar / Raphanus / Diabetes Mellitus Tipo 2 / Hipoglucemiantes / Insulina / Hígado Límite: Animals / Humans / Male Idioma: En Revista: J Med Food Asunto de la revista: CIENCIAS DA NUTRICAO / MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Glucemia / Brassica / Extractos Vegetales / Ratas Wistar / Raphanus / Diabetes Mellitus Tipo 2 / Hipoglucemiantes / Insulina / Hígado Límite: Animals / Humans / Male Idioma: En Revista: J Med Food Asunto de la revista: CIENCIAS DA NUTRICAO / MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos