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Transgender Women With Suppressed Testosterone Display Lower Burden of Coronary Disease Than Matched Cisgender Men.
Lake, Jordan E; Feng, Han; Hyatt, Ana N; Miao, Hongyu; Debroy, Paula; Funderburg, Nicholas; Ailstock, Kate; Dobs, Adrian; Haberlen, Sabina; Magnani, Jared W; Margolick, Joseph B; McGowan, Kate; Palella, Frank J; Witt, Mallory D; Bhasin, Shalender; Budoff, Matthew J; Post, Wendy S; Brown, Todd T.
Afiliación
  • Lake JE; Department of Medicine, UTHealth Houston, Houston, TX 77030, USA.
  • Feng H; Tulane Research and Innovation for Arrhythmia Discoveries-TRIAD Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Hyatt AN; Department of Medicine, UTHealth Houston, Houston, TX 77030, USA.
  • Miao H; Department of Statistics and College of Nursing, Florida State University, Tallahassee, FL 32306, USA.
  • Debroy P; Department of Medicine, UTHealth Houston, Houston, TX 77030, USA.
  • Funderburg N; Division of Medical Laboratory Science, The Ohio State University, Columbus, OH 43210, USA.
  • Ailstock K; Division of Medical Laboratory Science, The Ohio State University, Columbus, OH 43210, USA.
  • Dobs A; Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Haberlen S; Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Magnani JW; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  • Margolick JB; Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
  • McGowan K; Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Palella FJ; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Witt MD; Department of Medicine, Lundquist Institute, Torrance, CA 90502, USA.
  • Bhasin S; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Budoff MJ; Department of Medicine, Lundquist Institute, Torrance, CA 90502, USA.
  • Post WS; Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Brown TT; Department of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
J Endocr Soc ; 8(8): bvae120, 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38974987
ABSTRACT
Context Cardiovascular disease (CVD) in transgender women (TW) may be affected by gender-affirming hormone therapy (GAHT) and HIV, but few data compare TW on contemporary GAHT to well-matched controls.

Objective:

We compared CVD burden and biomarker profiles between TW and matched cisgender men (CM).

Methods:

Adult TW on GAHT (n = 29) were recruited for a cross-sectional study (2018-2020). CM (n = 48) from the former Multicenter AIDS Cohort Study were matched 21 to TW on HIV serostatus, age ±5 years, race/ethnicity, BMI category and antiretroviral therapy (ART) type. Cardiac parameters were measured by CT and coronary atherosclerosis by coronary CT angiography; sex hormone and biomarker concentrations were measured centrally from stored samples.

Results:

Overall, median age was 53 years and BMI 29 kg/m2; 69% were non-white. All participants with HIV (71%) had viral suppression on ART. Only 31% of TW had testosterone suppression (<50 ng/dL, TW-S). Traditional CVD risk factors were similar between groups, except that TW-S had higher BMI than TW with non-suppressed testosterone (TW-T). TW-S had no evidence of non-calcified coronary plaque or advanced coronary stenosis, whereas TW-T and CM had similar burden. TW had lower prevalence of any coronary plaque, calcified plaque and mixed plaque than CM, regardless of testosterone concentrations and HIV serostatus. Estradiol but not testosterone concentrations moderately and negatively correlated with the presence of coronary plaque and stenosis. Small sample size limited statistical power.

Conclusion:

Older TW with suppressed total testosterone on GAHT had no CT evidence of non-calcified coronary plaque or advanced coronary stenosis. Longitudinal studies to understand relationships between GAHT and CVD risk in TW are needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Endocr Soc Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Endocr Soc Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos