Your browser doesn't support javascript.
loading
An age-and sex-matched postoperative therapy should be required in thyroid papillary carcinoma.
Yan, Caigu; Sun, Jinjin; He, Xianghui; Jia, Lanning.
Afiliación
  • Yan C; Department of General Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.
  • Sun J; Department of General Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.
  • He X; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
  • Jia L; Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Front Endocrinol (Lausanne) ; 15: 1339191, 2024.
Article en En | MEDLINE | ID: mdl-38974575
ABSTRACT
Background and

purpose:

Thyroid papillary carcinoma (PTC) had a high possibility of recurrence after surgery, and thyroid stimulating hormone (TSH) suppression and radioactive iodine (131I) were used for postoperative therapy. This study explored the potential mechanism of lymph node metastasis (LNM) and aimed to develop differentiated treatments for PTC.

Method:

This study explored the risk factors of lymph node metastasis in PTC by analyzing the clinical information of 2073 cases. The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) and the Gene Expression Omnibus (GEO) databases of gene expression were analyzed to identify the interrelationships between gene expression to phenotype.

Results:

Analyzing clinical data, we found that male gender, younger age, larger tumor size, and extra-thyroidal extension (ETE) were risk significant risk factors for lymph node metastasis(P<0.05). Conversely, thyroid function parameters such as TSH, FT3, FT4, TSH/FT3, and TSH/FT4 didn't correlate with LNM(P>0.05), and TSH levels were observed to be higher in females(P<0.05). Gene expression analysis revealed that SLC5A5 was down-regulated in males, younger individuals, and those with lymph node metastasis, and a lower level of SLC5A5 was associated with a worse disease-free survival(P<0.05). Additionally, our examination of single-cell RNA sequencing (scRNA-seq) data indicated that SLC5A5 expression was reduced in tumors and lymph node metastasis samples, correlating positively with the expression of TSHR.

Conclusion:

The impact of TSH on PTC behavior remained unclear, while the capacity for absorbing 131I in dependence on SLC5A5 showed variations across different genders and ages. We conclude that postoperative treatment of PTC should take into account the differences caused by gender and age.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Cáncer Papilar Tiroideo / Metástasis Linfática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Cáncer Papilar Tiroideo / Metástasis Linfática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza