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Astrocytoma with high-grade features and MYBL1-MMP16 fusion.
Alarfaj, Abdullah; Pollock, Brooke; Sagga, Abdelaziz; Das, Sumit; Chow, Michael.
Afiliación
  • Alarfaj A; Department of Neurosurgery, University of Alberta, King Faisal University, Office of Postgraduate Surgical Education, University of Alberta, Edmonton, Canada.
  • Pollock B; Department of Neurosurgery, University of Alberta, Office of Postgraduate Surgical Education, University of Alberta, Edmonton, Canada.
  • Sagga A; Department of Neurosurgery, University of Alberta, King Fahad Medical City, Office of Postgraduate Surgical Education, University of Alberta, Edmonton, Canada.
  • Das S; Department of Neuropathology, University of Alberta, Walter MacKenzie Health Sciences Centre, Edmonton, Canada.
  • Chow M; Department of Neurosurgery, University of Alberta, Office of Postgraduate Surgical Education, University of Alberta, Edmonton, Canada.
Surg Neurol Int ; 15: 203, 2024.
Article en En | MEDLINE | ID: mdl-38974570
ABSTRACT

Background:

Gliomas represent the most common primary intraparenchymal brain tumors in adult and pediatric patients. Neuropathological work-up of these gliomas typically entails the determination of isocitrate dehydrogenase (IDH) mutational status, presence or absence of 1p/19q co-deletion, and O6 methylguanine-DNA methyl-transferase (MGMT) promoter methylation status. Case Description We present here an unusual case of a posterior fossa tumor in a 51-year-old female, which was initially diagnosed as astrocytoma with some high-grade features that recurred, displaying even more aggressive features such as infiltration and increased proliferative activity. Both the initially resected and recurrent tumor revealed MYBL1-MMP16 fusion, which is much more commonly found in pediatric low-grade gliomas and, to our knowledge has not been described in the context of an adult glioma.

Conclusion:

The significance of MYBL1-MMP16 fusion in adult gliomas in relation to survival and likelihood of recurrence is, therefore, unknown and requires more extensive research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Surg Neurol Int Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Surg Neurol Int Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos