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Variability of Resting Carbon Dioxide Tension in Patients with Intracranial Steno-occlusive Disease.
Plitman, Eric; Venkatraghavan, Lashmi; Agrawal, Sanket; Raghavan, Vishvak; Chowdhury, Tumul; Sobczyk, Olivia; Sayin, Ece Su; Poublanc, Julien; Duffin, James; Mikulis, David; Fisher, Joseph.
Afiliación
  • Plitman E; Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Venkatraghavan L; Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Agrawal S; Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Raghavan V; Department of Computer Science, Faculty of Science, McGill University, Montreal, Quebec, Canada.
  • Chowdhury T; Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Sobczyk O; Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Sayin ES; Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, ON, Canada.
  • Poublanc J; Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, ON, Canada.
  • Duffin J; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  • Mikulis D; Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, ON, Canada.
  • Fisher J; Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Asian J Neurosurg ; 19(2): 235-241, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38974441
ABSTRACT
Introduction Controlling the partial pressure of carbon dioxide (PaCO 2 ) is an important consideration in patients with intracranial steno-occlusive disease to avoid reductions in critical perfusion from vasoconstriction due to hypocapnia, or reductions in blood flow due to steal physiology during hypercapnia. However, the normal range for resting PCO 2 in this patient population is not known. Therefore, we investigated the variability in resting end-tidal PCO 2 (P ET CO 2 ) in patients with intracranial steno-occlusive disease and the impact of revascularization on resting P ET CO 2 in these patients. Setting and Design Tertiary care center, retrospective chart review Materials and Methods We collected resting P ET CO 2 values in adult patients with intracranial steno-occlusive disease who presented to our institution between January 2010 and June 2021. We also explored postrevascularization changes in resting P ET CO 2 in a subset of patients. Results Two hundred and twenty-seven patients were included [moyamoya vasculopathy ( n = 98) and intracranial atherosclerotic disease ( n = 129)]. In the whole cohort, mean ± standard deviation resting P ET CO 2 was 37.8 ± 3.9 mm Hg (range 26-47). In patients with moyamoya vasculopathy and intracranial atherosclerotic disease, resting P ET CO 2 was 38.4 ± 3.6 mm Hg (range 28-47) and 37.4 ± 4.1 mm Hg (range 26-46), respectively. A trend was identified suggesting increasing resting P ET CO 2 after revascularization in patients with low preoperative resting P ET CO 2 (<38 mm Hg) and decreasing resting P ET CO 2 after revascularization in patients with high preoperative resting P ET CO 2 (>38 mm Hg). Conclusion This study demonstrates that resting P ET CO 2 in patients with intracranial steno-occlusive disease is highly variable. In some patients, there was a change in resting P ET CO 2 after a revascularization procedure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Asian J Neurosurg Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Asian J Neurosurg Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: India