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Contemporary Review of the Management and Treatment of Young Breast Cancer Patients.
Vuong, Brooke; Jacinto, Ana I; Chang, Sharon B; Kuehner, Gillian E; Savitz, Alison C.
Afiliación
  • Vuong B; Department of Surgery, Kaiser Permanente South Sacramento Medical Center, Sacramento, CA. Electronic address: brookevuong@gmail.com.
  • Jacinto AI; Department of Surgery, University of California, Davis, Sacramento, CA.
  • Chang SB; Department of Surgery, Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA.
  • Kuehner GE; Department of Surgery, Kaiser Permanente Vallejo Medical Center, Vallejo, CA.
  • Savitz AC; Department of Surgery, Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA.
Clin Breast Cancer ; 2024 Jun 07.
Article en En | MEDLINE | ID: mdl-38972829
ABSTRACT
Approximately 11% of all new breast cancer cases annually are diagnosed in young women, and this continues to be the leading cause of death in women age 20 to 49. Young, premenopausal breast cancer patients present with more advanced stages and with a higher proportion of aggressive subtypes such as triple negative and HER2-enriched tumors. Recently, the United States Preventive Services Task Force (USPSTF) lowered the age threshold to initiate screening mammograms to age 40 to aid in earlier detection. Young age at diagnosis increases the likelihood for a pathogenic mutation, and genetic testing is recommended for all patients age 50 and younger. This population is often underrepresented in landmark clinical trials, and data is extrapolated for the treatment of young women with breast cancer. Despite there being no survival benefit to more extensive surgical treatments, such as mastectomy or contralateral prophylactic mastectomy, many patients opt against breast conservation. Young patients with breast cancer face issues related to treatment toxicities, potential overtreatment of their disease, mental health, sexual health, and fertility preservation. This unique population requires a multidisciplinary care team of physicians, surgeons, genetic counselors, fertility specialists, mental health professionals, physical therapists, and dieticians to provide individualized, comprehensive care. Our aim is to (1) provide a narrative review of retrospective studies, relevant society guidelines, and clinical trials focused on the contemporary treatment and management of YBC patients and (2) discuss important nuances in their care as a guide for members of their multidisciplinary treatment team.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Breast Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Breast Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos