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First-Generation OTC Antihistamine Use and Voice Function in Individuals with Allergic Rhinitis: A Preliminary Report of Clinically Impactful Findings.
Hall-Landers, Rebecca J; Morton-Jones, Mariah E; Plexico, Laura W; Spray, Gregory J; Sandage, Mary J.
Afiliación
  • Hall-Landers RJ; Department of Speech, Language, & Hearing Sciences, Auburn University, Auburn, Alabama.
  • Morton-Jones ME; School of Kinesiology, Auburn University, Auburn, Alabama.
  • Plexico LW; Department of Speech, Language, & Hearing Sciences, Auburn University, Auburn, Alabama.
  • Spray GJ; Department of Speech, Language, & Hearing Sciences, Auburn University, Auburn, Alabama.
  • Sandage MJ; Department of Speech, Language, & Hearing Sciences, Auburn University, Auburn, Alabama. Electronic address: sandamj@auburn.edu.
J Voice ; 2024 Jul 06.
Article en En | MEDLINE | ID: mdl-38972776
ABSTRACT

PURPOSE:

The primary goal of this investigation was to characterize the effect of the first-generation, over-the-counter antihistamine Chlor-Trimeton on laryngeal structure and function in a previously unstudied population - individuals diagnosed with allergic rhinitis who routinely take over-the-counter antihistamines and deny the experience or diagnosis of voice disorder. STUDY

DESIGN:

Prospective within-participant multimodality repeated measures design.

METHODS:

Eight consented participants (seven females, one male) previously diagnosed with allergic rhinitis and without history of voice disorder who routinely took over-the-counter antihistamines completed the study. Volunteers completed the following measures before and 2hours after antihistamine administration perceptual vocal function measures, phonation threshold pressure (PTP), acoustic measures, and laryngeal imaging. All pre- and post-administration data were descriptively analyzed for clinically significant change.

RESULTS:

No clinically significant differences were identified for any acoustic or aerodynamic measures taken. Analyses of laryngeal imaging data indicated that all participants had evidence of mucosal changes in one or more of the following parameters increased vascularity, mucus in the anterior commissure, and vocal fold color changes, all of which are consistent with prior descriptions of allergy larynx.

CONCLUSIONS:

Empirical study of laryngeal appearance in individuals diagnosed with allergic rhinitis, affirmed clinical observations of laryngeal tissue changes consistent with allergy larynx. Stable PTP suggests potential vocal fold cover adaptations from routine use of over-the-counter antihistamines that may buffer the typical desiccating effect on voice function observed in prior studies of healthy individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Voice Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Voice Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos