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Interobserver Variability in the Histopathological Evaluation of Melanoma: Analysis of 60 Cases.
Sanz-Motilva, V; Martorell, A; Manrique-Silva, E; Terradez-Mas, L; Requena, C; Traves, V; Sanmartín, O; Rodríguez-Peralto, J L; Nagore, E.
Afiliación
  • Sanz-Motilva V; Department of Dermatology, Hospital de Manises, Valencia, Spain.
  • Martorell A; Department of Dermatology, Hospital de Manises, Valencia, Spain.
  • Manrique-Silva E; Department of Dermatology, Fundación Instituto Valenciano de Oncología, Valencia, Spain.
  • Terradez-Mas L; Department of Pathology, Hospital Clínico Universitario de Valencia, Valencia, Spain.
  • Requena C; Department of Dermatology, Fundación Instituto Valenciano de Oncología, Valencia, Spain.
  • Traves V; Department of Pathology, Fundación Instituto Valenciano de Oncología, Valencia, Spain.
  • Sanmartín O; Department of Dermatology, Fundación Instituto Valenciano de Oncología, Valencia, Spain.
  • Rodríguez-Peralto JL; Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Nagore E; Department of Dermatology, Fundación Instituto Valenciano de Oncología, Valencia, Spain. Electronic address: eduardo.nagore@ucv.es.
Actas Dermosifiliogr ; 2024 Jul 05.
Article en En, Es | MEDLINE | ID: mdl-38972585
ABSTRACT

INTRODUCTION:

Since the field of dermatopathology is not an exact science, it is subject to personal subjectivity, which sometimes causes disagreements on the diagnosis and assessment of some histological features. In the case of melanoma, some variables such as regression are associated with low interobserver agreement. On the contrary, other variables such as the measurement of Breslow thickness show high reproducibility.

OBJECTIVE:

The main objective of our study was to investigate multiple features of 60 consecutive cases of melanoma to establish interobserver reproducibility. METHODS AND MAIN

RESULTS:

We conducted an observational and descriptive study at Hospital de Manises, Valencia, Spain, IVO Foundation, Valencia, Spain, and Hospital 12 de Octubre, Madrid, Spain. The mean level of agreement of all study variables was moderate (Cohen's kappa coefficient statistic=0.5). The highest agreement corresponded to polypoid morphology, pigmentation, ulceration, and solar elastosis. On the other hand, the lowest level agreement was reached for the presence of cellular pleomorphism and tumor necrosis.

CONCLUSIONS:

Our mean level of agreement was moderate, which reflects that some of the measured characteristics such as cellular pleomorphism or the presence of necrosis cannot be used for future studies or must be redefined and their reproducibility, reestablished. When conducting a research study, it is necessary to analyze the study variables to demonstrate their validity to measure or classify a certain feature. It is also advisable to warrant that that the variables are reproducible to be able to use them for other studies or in the routine clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En / Es Revista: Actas Dermosifiliogr Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: España
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En / Es Revista: Actas Dermosifiliogr Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: España