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Pulmonary arterial hypertension: Navigating the pathways of progress in diagnosis, treatment, and patient care.
Azaredo Raposo, Miguel; Inácio Cazeiro, Daniel; Guimarães, Tatiana; Lousada, Nuno; Freitas, Céline; Brito, Joana; Martins, Susana; Resende, Catarina; Dorfmüller, Peter; Luís, Rita; Moreira, Susana; Alves da Silva, Pedro; Moita, Luís; Oliveira, Mário; Pinto, Fausto J; Plácido, Rui.
Afiliación
  • Azaredo Raposo M; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal.
  • Inácio Cazeiro D; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal.
  • Guimarães T; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal.
  • Lousada N; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal.
  • Freitas C; Association for Research and Development of Faculty of Medicine (AIDFM), Cardiovascular Research Support Unit (GAIC), Lisbon, Portugal.
  • Brito J; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal.
  • Martins S; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal.
  • Resende C; Rheumatology Department, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.
  • Dorfmüller P; Department of Pathology, University Hospital of Giessen and Marburg, Giessen, Germany; Institute for Lung Health, Giessen, Germany.
  • Luís R; Pathology Department, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal; Pathology Department, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal; Pathology Institute, Faculdade Medicina Universidade Lisboa, Lisbon, Portugal.
  • Moreira S; Pulmonology Department, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.
  • Alves da Silva P; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal.
  • Moita L; Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
  • Oliveira M; Cardiology Department, CUF Tejo, Lisbon, Portugal.
  • Pinto FJ; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal.
  • Plácido R; Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculty of Medicine, Lisbon, Portugal; Cardiology Department, CUF Tejo, Lisbon, Portugal. Electronic address: placidorui@gmail.com.
Rev Port Cardiol ; 2024 Jul 05.
Article en En, Pt | MEDLINE | ID: mdl-38972452
ABSTRACT
Pulmonary arterial hypertension (PAH) is a form of precapillary pulmonary hypertension caused by a complex process of endothelial dysfunction and vascular remodeling. If left untreated, this progressive disease presents with symptoms of incapacitating fatigue causing marked loss of quality of life, eventually culminating in right ventricular failure and death. Patient management is complex and based on accurate diagnosis, risk stratification, and treatment initiation, with close monitoring of response and disease progression. Understanding the underlying pathophysiology has enabled the development of multiple drugs directed at different targets in the pathological chain. Vasodilator therapy has been the mainstay approach for the last few years, significantly improving quality of life, functional status, and survival. Recent advances in therapies targeting dysfunctional pathways beyond endothelial dysfunction may address the fundamental processes underlying the disease, raising the prospect of increasingly effective options for this high-risk group of patients with a historically poor prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En / Pt Revista: Rev Port Cardiol Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Portugal
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En / Pt Revista: Rev Port Cardiol Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Portugal