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Vitifolignans, 3,4-dibenzyltetrahydrofuran lignans from Anemone vitifolia Buch.-Ham.
Lu, Ya; Huang, Xueyan; Adpressa, Donovon A; Mou, Linyun; Taylor, Peter R; Clark, Benjamin R.
Afiliación
  • Lu Y; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, Tianjin, PR China.
  • Huang X; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, Tianjin, PR China.
  • Adpressa DA; Loxo Oncology, Louisville, CO, 80027, United States.
  • Mou L; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, Tianjin, PR China.
  • Taylor PR; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, Tianjin, PR China.
  • Clark BR; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, Tianjin, PR China. Electronic address: bclark@tju.edu.cn.
Phytochemistry ; 226: 114217, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38972442
ABSTRACT
Anemone vitifolia is a small herb found in Asia that is used to treat a range of diseases in Chinese traditional medicine. GNPS-based molecular networking of an Anemone vitifolia specimen revealed the presence of a network containing numerous ions indicating the presence of lignans, several of which suggested that there might be previously undescribed compounds in the extract. Fractionation of the organic extract yielded five undescribed lignans, the vitifolignans, together with one known. The structures were identified based on extensive spectroscopic data analysis (NMR, HR-ESI-MS, and UV), coupling constant calculation and comparison with reported data. Their absolute configurations were determined by comparison of experimental ECD spectra with calculated spectra. Compounds 4/5 showed weak inhibition of LPS-induced NO production in mouse mononuclear macrophages.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Lignanos / Anemone / Óxido Nítrico Límite: Animals Idioma: En Revista: Phytochemistry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Lignanos / Anemone / Óxido Nítrico Límite: Animals Idioma: En Revista: Phytochemistry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido