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2D nanomaterials-based delivery systems and their potentials in anticancer synergistic photo-immunotherapy.
Luo, Yankun; Chen, Ming; Zhang, Ting; Peng, Qiang.
Afiliación
  • Luo Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
  • Chen M; West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
  • Zhang T; Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: zhangtingyx@yeah.net.
  • Peng Q; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: qiangpengzz@scu.edu.cn.
Colloids Surf B Biointerfaces ; 242: 114074, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38972257
ABSTRACT
As the field of cancer therapeutics evolves, integrating two-dimensional (2D) nanomaterials with photo-immunotherapy has emerged as a promising approach with significant potential to augment cancer treatment efficacy. These 2D nanomaterials include graphene-based 2D nanomaterials, 2D MXenes, 2D layered double hydroxides, black phosphorus nanosheets, 2D metal-organic frameworks, and 2D transition metal dichalcogenides. They exhibit high load capacities, multiple functionalization pathways, optimal biocompatibility, and physiological stability. Predominantly, they function as anti-tumor delivery systems, amalgamating diverse therapeutic modalities, most notably phototherapy and immunotherapy, and the former is a recognized non-invasive treatment modality, and the latter represents the most promising anti-cancer strategy presently accessible. Thus, integrating phototherapy and immunotherapy founded on 2D nanomaterials unveils a novel paradigm in the war against cancer. This review delineates the latest developments in 2D nanomaterials as delivery systems for synergistic photo-immunotherapy in cancer treatment. We elaborate on the burgeoning realm of photo-immunotherapy, exploring the interplay between phototherapy and enhanced immune cells, immune response modulation, or immunosuppressive tumor microenvironments. Notably, the strategies to augment photo-immunotherapy have also been discussed. Finally, we discuss the challenges and future perspectives of these 2D nanomaterials in photo-immunotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fototerapia / Sistemas de Liberación de Medicamentos / Nanoestructuras / Inmunoterapia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fototerapia / Sistemas de Liberación de Medicamentos / Nanoestructuras / Inmunoterapia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos