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An agent-based model for cell microenvironment simulation using FLAMEGPU2.
Borau, C; Chisholm, R; Richmond, P; Walker, D.
Afiliación
  • Borau C; Multiscale in Mechanical and Biological Engineering (M2BE), Mechanical Engineering Dept, University of Zaragoza, Zaragoza, Spain; Centro Universitario de la Defensa, Zaragoza, Spain.
  • Chisholm R; Department of Computer Science and Insigneo Institute of in Silico Medicine, University of Sheffield, Sheffield, UK.
  • Richmond P; Department of Computer Science and Insigneo Institute of in Silico Medicine, University of Sheffield, Sheffield, UK.
  • Walker D; Department of Computer Science and Insigneo Institute of in Silico Medicine, University of Sheffield, Sheffield, UK. Electronic address: d.c.walker@sheffield.ac.uk.
Comput Biol Med ; 179: 108831, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38970834
ABSTRACT
This work presents an advanced agent-based model developed within the FLAMEGPU2 framework, aimed at simulating the intricate dynamics of cell microenvironments. Our primary objective is to showcase FLAMEGPU2's potential in modelling critical features such as cell-cell and cell-ECM interactions, species diffusion, vascularisation, cell migration, and/or cell cycling. By doing so, we provide a versatile template that serves as a foundational platform for researchers to model specific biological mechanisms or processes. We highlight the utility of our approach as a microscale component within multiscale frameworks. Through four example applications, we demonstrate the model's versatility in capturing phenomena such as strain-stiffening behaviour of hydrogels, cell migration patterns within hydrogels, spheroid formation and fibre reorientation, and the simulation of diffusion processes within a vascularised and deformable domain. This work aims to bridge the gap between computational efficiency and biological fidelity, offering a scalable and flexible platform to advance our understanding of tissue biology and engineering.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simulación por Computador / Microambiente Celular / Modelos Biológicos Límite: Humans Idioma: En Revista: Comput Biol Med Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simulación por Computador / Microambiente Celular / Modelos Biológicos Límite: Humans Idioma: En Revista: Comput Biol Med Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos