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Feasibility and success of a non-sedated brain MRI training protocol in 7-year-old children from rural and semi-rural Colombia.
Corn, Elizabeth; Andringa-Seed, Regan; Williams, Meagan E; Arroyave-Wessel, Margarita; Tarud, Raul; Vezina, Gilbert; Podolsky, Robert H; Kapse, Kushal; Limperopoulos, Catherine; Berl, Madison M; Cure, Carlos; Mulkey, Sarah B.
Afiliación
  • Corn E; Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.
  • Andringa-Seed R; Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.
  • Williams ME; Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.
  • Arroyave-Wessel M; Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.
  • Tarud R; Sabbag Radiólogos, Barranquilla, Colombia.
  • Vezina G; Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington DC, USA.
  • Podolsky RH; Division of Biostatistics and Study Methodology, Children's National Hospital, Washington DC, USA.
  • Kapse K; Developing Brain Institute, Children's National Hospital, Washington DC, USA.
  • Limperopoulos C; Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.
  • Berl MM; Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington DC, USA.
  • Cure C; Developing Brain Institute, Children's National Hospital, Washington DC, USA.
  • Mulkey SB; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington DC, USA.
Pediatr Radiol ; 54(9): 1513-1522, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38970708
ABSTRACT

BACKGROUND:

Brain magnetic resonance imaging (MRI) is a crucial tool for clinical evaluation of the brain and neuroscience research. Obtaining successful non-sedated MRI in children who live in resource-limited settings may be an additional challenge.

OBJECTIVE:

To present a feasibility study of a novel, low-cost MRI training protocol used in a clinical research study in a rural/semi-rural region of Colombia and to examine neurodevelopmental factors associated with successful scans. MATERIALS AND

METHODS:

Fifty-seven typically developing Colombian children underwent a training protocol and non-sedated brain MRI at age 7. Group training utilized a customized booklet, an MRI toy set, and a simple mock scanner. Children attended MRI visits in small groups of two to three. Resting-state functional and structural images were acquired on a 1.5-Tesla scanner with a protocol duration of 30-40 minutes. MRI success was defined as the completion of all sequences and no more than mild motion artifact. Associations between the Wechsler Preschool and Primary Scale of Intelligence (WPPSI), Movement Assessment Battery for Children (MABC), Behavioral Rating Inventory of Executive Function (BRIEF), Child Behavior Checklist (CBCL), and Adaptive Behavior Assessment System (ABAS) scores and MRI success were analyzed.

RESULTS:

Mean (SD) age at first MRI attempt was 7.2 (0.2) years (median 7.2 years, interquartile range 7.1-7.3 years). Twenty-six (45.6%) participants were male. Fifty-one (89.5%) children were successful across two attempts; 44 (77.2%) were successful on their first attempt. Six (10.5%) were unsuccessful due to refusal or excessive motion. Age, sex, and scores across all neurodevelopmental assessments (MABC, TVIP, ABAS, BRIEF, CBCL, NIH Toolbox Flanker, NIH Toolbox Pattern Comparison, WPPSI) were not associated with likelihood of MRI success (P=0.18, 0.19, 0.38, 0.92, 0.84, 0.80, 1.00, 0.16, 0.75, 0.86, respectively).

CONCLUSION:

This cohort of children from a rural/semi-rural region of Colombia demonstrated comparable MRI success rates to other published cohorts after completing a low-cost MRI familiarization training protocol suitable for low-resource settings. Achieving non-sedated MRI success in children in low-resource and international settings is important for the continuing diversification of pediatric research studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Rural / Imagen por Resonancia Magnética / Estudios de Factibilidad Límite: Child / Female / Humans / Male País/Región como asunto: America do sul / Colombia Idioma: En Revista: Pediatr Radiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Rural / Imagen por Resonancia Magnética / Estudios de Factibilidad Límite: Child / Female / Humans / Male País/Región como asunto: America do sul / Colombia Idioma: En Revista: Pediatr Radiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania