Your browser doesn't support javascript.
loading
Distinct Substrates of Idiopathic Ventricular Fibrillation Revealed by Arrhythmia Characteristics on Implantable Cardioverter-Defibrillator.
Haïssaguerre, Michel; Sellal, Jean-Marc; Benali, Karim; de Becker, Benjamin; Defaye, Pascal; Pascale, Patrizio; Martins, Raphael; Mabo, Philippe; Xhaet, Olivier; Extramiana, Fabrice; Surget, Elodie; Lavergne, Thomas; Marijon, Eloi; Adragao, Pedro; Carvalho, Maria Salomé; Milliez, Paul-Ursmar; Laredo, Mickael; Gandjbakhch, Estelle; Giustetto, Carla; Gaita, Fiorenzo; Tilz, Roland; Jesel-Morel, Laurence; Steinfurt, Johannes; Arentz, Thomas; Knecht, Sebastien; Duytschaever, Mattias; Roten, Laurent; Reichlin, Tobias; Fatemi, Marjaneh; Mansourati, Jacques; Kouakam, Claude; Bessière, Francis; Chevalier, Philippe; Tadros, Rafik; Macle, Laurent; Gallego, Francisco; Hadjis, Alexios; Sacher, Frederic; Pereira, Dylan; Hourdain, Jerome; Deharo, Jean-Claude; Eschalier, Romain; Massoulié, Grégoire; Maury, Philippe; Latcu, Decebal Gabriel; Anselme, Frederic; Duchateau, Josselin; Tixier, Romain; Nademanee, Koonlawee; Nogami, Akihiko.
Afiliación
  • Haïssaguerre M; IHU Liryc, Electrophysiology and Heart Modeling Institute, Foundation Bordeaux Université, Bordeaux, France; Cardiac electrophysiology and stimulation, Cardiology Department, Bordeaux University Hospital (CHU), Pessac, France. Electronic address: michel.haissaguerre@chu-bordeaux.fr.
  • Sellal JM; Cardiology Department, Nancy University Hospital (CHRU), Nancy, France.
  • Benali K; Cardiac electrophysiology and stimulation, Cardiology Department, Bordeaux University Hospital (CHU), Pessac, France; Department of Cardiac Electrophysiology, Saint-Etienne University Hospital Center, Jean-Monnet University, Saint-Etienne, France.
  • de Becker B; AZ Sint-Jan Brugge AV, Bruges Hospital, Bruges, Belgium.
  • Defaye P; Rhythmology and Cardiac stimulation Unit, Grenoble University Hospital (CHU), Grenoble, France.
  • Pascale P; Cardiology Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Martins R; Cardiology Department, Rennes University Hospital (CHU), Rennes, France.
  • Mabo P; Cardiology Departement, Namur University Hospital (CHU UCL Namur), Yvoir, Belgium.
  • Xhaet O; Cardiology Department, APHP Hôpital Bichat, Paris, France.
  • Extramiana F; Cardiology Department, Rhythmology Unit, Hôpital Européen Georges Pompidou, Paris, France.
  • Surget E; Heart Rhythm Centre, Hospital da Luz, Lisbon, Portugal.
  • Lavergne T; Cardiology Department, Caen Normandie University Hospital (CHU), Caen, France.
  • Marijon E; Pitié-Salpêtrière University Hospital, Institute of Cardiology, Paris, France.
  • Adragao P; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Carvalho MS; Heart Rhythm Centre, Hospital da Luz, Lisbon, Portugal.
  • Milliez PU; Cardiology Department, Caen Normandie University Hospital (CHU), Caen, France.
  • Laredo M; Pitié-Salpêtrière University Hospital, Institute of Cardiology, Paris, France.
  • Gandjbakhch E; Pitié-Salpêtrière University Hospital, Institute of Cardiology, Paris, France.
  • Giustetto C; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Gaita F; Universitätsklinikum Schleswig-Holstein (UKSH), Klinik für Rhythmologie, Lübeck, Germany.
  • Tilz R; Cardiology Department, Strasbourg University Hospital (CHRU), Strasbourg, France.
  • Jesel-Morel L; Cardiology Department, Strasbourg University Hospital (CHRU), Strasbourg, France.
  • Steinfurt J; Department of Cardiology, Universitäts-Herzzentrum Freiburg - Bad Krozingen, Freiburg, Germany.
  • Arentz T; Department of Cardiology, Universitäts-Herzzentrum Freiburg - Bad Krozingen, Freiburg, Germany.
  • Knecht S; AZ Sint-Jan Brugge AV, Bruges Hospital, Bruges, Belgium.
  • Duytschaever M; AZ Sint-Jan Brugge AV, Bruges Hospital, Bruges, Belgium.
  • Roten L; Inselspital, Bern University Hospital, University Clinic for Cardiology, Bern, Switzerland.
  • Reichlin T; Inselspital, Bern University Hospital, University Clinic for Cardiology, Bern, Switzerland.
  • Fatemi M; Cardiology Department, Brest University Hospital(CHU), Brest, France.
  • Mansourati J; Cardiology Department, Brest University Hospital(CHU), Brest, France.
  • Kouakam C; Cardiology Department, Lille University Hospital (CHRU), Lille, France.
  • Bessière F; Cardiac Rhythmology Department, Hôpital cardiologique Louis Pradel, Hospices Civils de Lyon, Lyon, France.
  • Chevalier P; Cardiac Rhythmology Department, Hôpital cardiologique Louis Pradel, Hospices Civils de Lyon, Lyon, France.
  • Tadros R; Montreal Heart Institute (ICM), Montréal, Canada.
  • Macle L; Montreal Heart Institute (ICM), Montréal, Canada.
  • Gallego F; Montreal Heart Institute (ICM), Montréal, Canada.
  • Hadjis A; Electrophysiology Unit, Cardiology Department, Sacré-Coeur Hospital of Montréal (HSCM), Montréal, Canada.
  • Sacher F; Cardiac electrophysiology and stimulation, Cardiology Department, Bordeaux University Hospital (CHU), Pessac, France; Reference Center for Hereditary Rhythmic Diseases and Sudden Death Prevention (CMARY), Cardiology Department, Bordeaux University Hospital (CHU), Pessac, France.
  • Pereira D; Cardiology Department, Tours University Hospital (CHU), Tours, France.
  • Hourdain J; Cardiology Department, Tours University Hospital (CHU), Tours, France.
  • Deharo JC; Cardiology Department, Marseille University Hospital La Timone (AP-HM), Marseille, France.
  • Eschalier R; Cardiology Department, Marseille University Hospital La Timone (AP-HM), Marseille, France; Cardiology Department, Clermont-Ferrand University Hospital, (CHU), Clermont-Ferrand, France.
  • Massoulié G; Cardiology Department, Clermont-Ferrand University Hospital, (CHU), Clermont-Ferrand, France.
  • Maury P; Cardiology Department, Rangueil University Hospital (CHU), Toulouse, France.
  • Latcu DG; Cardiology Department, Princess Grace Hospital, Monaco.
  • Anselme F; Cardiology Department, Rouen-Normandie University Hospital (CHU), Rouen, France.
  • Duchateau J; IHU Liryc, Electrophysiology and Heart Modeling Institute, Foundation Bordeaux Université, Bordeaux, France; Cardiac electrophysiology and stimulation, Cardiology Department, Bordeaux University Hospital (CHU), Pessac, France.
  • Tixier R; Cardiac electrophysiology and stimulation, Cardiology Department, Bordeaux University Hospital (CHU), Pessac, France.
  • Nademanee K; Pacific Rim Electrophysiology Research Institute at Bumrungrad Hospital, Bangkok, Thailand.
  • Nogami A; Tokyo Heart Rhythm Hospital, Tokyo, Japan.
JACC Clin Electrophysiol ; 2024 Jun 21.
Article en En | MEDLINE | ID: mdl-38970599
ABSTRACT

BACKGROUND:

Idiopathic ventricular fibrillation (IVF) can be associated with undetected distinct conditions such as microstructural cardiomyopathic alterations (MiCM) or Purkinje (Purk) activities with structurally normal hearts.

OBJECTIVE:

This study sought to evaluate the characteristics of recurrent VF recorded on implantable defibrillator electrograms, associated with these substrates.

METHODS:

This was a multicenter collaboration study. At 32 centers, we selected patients with an initial diagnosis of IVF and recurrent arrhythmia at follow-up without antiarrhythmic drugs, in whom mapping demonstrated Purk or MiCM substrate. We analyzed variables related to previous ectopy, sinus rate preceding VF, trigger, and initial VF cycle lengths. Logistic regression with cross validation was used to evaluate the performance of criteria to discriminate Purk or MiCM substrates.

RESULTS:

Among 95 patients (35 women, age 35 ± 11 years) meeting the inclusion criteria, IVF was associated with MiCM in 41 and Purk in 54 patients. A total of 117 arrhythmia recurrences including 91% VF were recorded on defibrillator. Three variables were mostly discriminant. Sinus tachycardia (≤570 ms) was more frequent in MiCM (35.9% vs 13.4%, P = 0.014) whereas short-coupled (<350 ms) triggers were most frequent in Purk-related VF (95.5% vs 23.1%, P = 0.001), which also had shorter VFCLs (182 ± 15 ms vs 215 ± 24 ms, P < 0.001).The multivariable combination provided the highest prediction (accuracy = 0.93 ± 0.05, range 0.833-1.000), discriminating 81% of IVF substrates with a high probability (>80%). Ectopy were inconsistently present before VF.

CONCLUSIONS:

Characteristics of arrhythmia recurrences on implantable cardioverter- defibrillator provide phenotypic markers of the distinct and hidden substrates underlying IVF. These findings have significant clinical and genetic implications.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Clin Electrophysiol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Clin Electrophysiol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos