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Prenatal LPS leads to increases in RAS expression within the PVN and overactivation of sympathetic outflow in offspring rats.
Hao, Xueqin; Long, Xueting; Fan, Lingling; Gou, Jijia; Liu, Yuchao; Fu, Yifan; Zhao, Huijuan; Xie, Xiaojuan; Wang, Dongmei; Liang, Gaofeng; Ye, Yujia; Wang, Jing; Li, Sanqiang; Zeng, Chunyu.
Afiliación
  • Hao X; Department of human Anatomy and Histoembryology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Long X; Department of Anesthesiology, the First affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China.
  • Fan L; Department of human Anatomy and Histoembryology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Gou J; Department of Physiology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Liu Y; Department of human Anatomy and Histoembryology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Fu Y; Department of human Anatomy and Histoembryology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Zhao H; Department of human Anatomy and Histoembryology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Xie X; Department of human Anatomy and Histoembryology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Wang D; Department of Anesthesiology, the First affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China.
  • Liang G; Department of Microbiology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Ye Y; Department of Pathology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.
  • Wang J; Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China. yeyj@ydyy.cn.
  • Li S; Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China. wangjing@ydyy.cn.
  • Zeng C; Department of Biochemistry, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China. sanqiangli2001@163.com.
Hypertens Res ; 47(9): 2363-2376, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38969805
ABSTRACT
The renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) are two major blood pressure-regulating systems. The link between the renal and cerebral RAS axes was provided by reflex activation of renal afferents and efferent sympathetic nerves. There is a self-sustaining enhancement of the brain and the intrarenal RAS. In this study, prenatal exposure to lipopolysaccharide (LPS) led to increased RAS activity in the paraventricular nucleus (PVN) and overactivation of sympathetic outflow, accompanied by increased production of reactive oxygen species (ROS) and disturbances between inhibitory and excitatory neurons in PVN. The AT1 receptor blocker losartan and α2 adrenergic receptor agonist clonidine in the PVN significantly decreased renal sympathetic nerve activity (RSNA) and synchronously reduced systolic blood pressure. Prenatal LPS stimulation caused H3 acetylation at H3K9 and H3K14 in the PVN, which suggested that epigenetic changes are involved in transmitting the prenatal adverse stimulative information to the next generation. Additionally, melatonin treatment during pregnancy reduced RAS activity and ROS levels in the PVN; balanced the activity of inhibitory and excitatory neurons in the PVN; increased urine sodium secretion; reduced RSNA and blood pressure. In conclusion, prenatal LPS leads to increased RAS expression within the PVN and overactivation of the sympathetic outflow, thereby contributing to hypertension in offspring rats. Melatonin is expected to be a promising agent for preventing prenatal LPS exposure-induced hypertension.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Núcleo Hipotalámico Paraventricular / Efectos Tardíos de la Exposición Prenatal / Sistema Renina-Angiotensina / Sistema Nervioso Simpático / Presión Sanguínea / Lipopolisacáridos Límite: Animals / Pregnancy Idioma: En Revista: Hypertens Res Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Núcleo Hipotalámico Paraventricular / Efectos Tardíos de la Exposición Prenatal / Sistema Renina-Angiotensina / Sistema Nervioso Simpático / Presión Sanguínea / Lipopolisacáridos Límite: Animals / Pregnancy Idioma: En Revista: Hypertens Res Asunto de la revista: ANGIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido