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An injectable exosome-loaded hyaluronic acid-polylysine hydrogel for cardiac repair via modulating oxidative stress and the inflammatory microenvironment.
Ren, Yuchen; Wang, Weitong; Yu, Chaojie; Wang, Yue; Qiu, Yuwei; Yue, Zhiwei; Yu, Qingyu; Lu, Jiajun; Che, Pengcheng; Li, Junjie; Sun, Hong.
Afiliación
  • Ren Y; Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China.
  • Wang W; Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China.
  • Yu C; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.
  • Wang Y; Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China.
  • Qiu Y; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.
  • Yue Z; Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China.
  • Yu Q; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.
  • Lu J; Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China.
  • Che P; School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan 063210, China. Electronic address: chepengcheng@ncst.edu.cn.
  • Li J; Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China. Electronic address: li41308@tju.edu.cn.
  • Sun H; Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China. Electronic address: sunhong@ncst.edu.cn.
Int J Biol Macromol ; 275(Pt 2): 133622, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38969034
ABSTRACT
Myocardial infarction (MI) is a serious cardiovascular disease with complex complications and high lethality. Currently, exosome (Exo) therapy has emerged as a promising treatment of ischemic MI due to its antioxidant, anti-inflammatory, and vascular abilities. However, traditional Exo delivery lacks spatiotemporal precision and targeting of microenvironment modulation, making it difficult to localize the lesion site for sustained effects. In this study, an injectable oxidized hyaluronic acid-polylysine (OHA-PL) hydrogel was developed to conveniently load adipose-derived mesenchymal stem cell exosomes (ADSC-Exos) and improve their retention under physiological conditions. The OHA-PL@Exo hydrogel with high spatiotemporal precision is transplanted minimally invasively into the ischemic myocardium to scavenge intracellular and extracellular reactive oxygen species, regulate macrophage polarization, and attenuate inflammation in the early phase of MI. In addition, this synergistic microenvironment modulation can effectively reduce myocardial fibrosis and ventricular remodeling, promote angiogenesis, and restore electrophysiological function in the late stage of MI. Therefore, this hyaluronic acid-polylysine to deliver exosomes has become a promising therapeutic strategy for myocardial repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polilisina / Estrés Oxidativo / Hidrogeles / Exosomas / Ácido Hialurónico / Inflamación Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polilisina / Estrés Oxidativo / Hidrogeles / Exosomas / Ácido Hialurónico / Inflamación Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos