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Enhancing electrical conductivity and mechanical properties of decellularized umbilical cord arteries using graphene coatings.
Karimi, Fateme; Alizadeh, Morteza; Bitaraf, Fateme Sadat; Shirshahi, Vahid.
Afiliación
  • Karimi F; Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Alizadeh M; Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Bitaraf FS; Department of Basic Sciences, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Shirshahi V; Department of Basic Sciences, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
J Biomed Mater Res B Appl Biomater ; 112(7): e35448, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38968133
ABSTRACT
Traditional decellularized bioscaffolds possessing intact vascular networks and unique architecture have been extensively studied as conduits for repairing nerve damage. However, they are limited by the absence of electrical conductivity, which is crucial for proper functioning of nervous tissue. This study focuses on investigating decellularized umbilical cord arteries by applying coatings of graphene oxide (GO) and reduced graphene oxide (RGO) to their inner surfaces. This resulted in a homogeneous GO coating that fully covered the internal lumen of the arteries. The results of electrical measurements demonstrated that the conductivity of the scaffolds could be significantly enhanced by incorporating RGO and GO conductive sheets. At a low frequency of 0.1 Hz, the electrical resistance level of the coated scaffolds decreased by 99.8% with RGO and 98.21% with GO, compared with uncoated scaffolds. Additionally, the mechanical properties of the arteries improved by 24.69% with GO and 32.9% with RGO after the decellularization process. The GO and RGO coatings did not compromise the adhesion of endothelial cells and promoted cell growth. The cytotoxicity tests revealed that cell survival rate increased over time with RGO, while it decreased with GO, indicating the time-dependent effect on the cytotoxicity of GO and RGO. Blood compatibility evaluations showed that graphene nanomaterials did not induce hemolysis but exhibited some tendency toward blood coagulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Umbilicales / Materiales Biocompatibles Revestidos / Conductividad Eléctrica / Grafito Límite: Animals / Humans Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Umbilicales / Materiales Biocompatibles Revestidos / Conductividad Eléctrica / Grafito Límite: Animals / Humans Idioma: En Revista: J Biomed Mater Res B Appl Biomater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos