From Gut Microbiomes to Infectious Pathogens: Neurological Disease Game Changers.

K M, Muhasina; Ghosh, Puja; Nagappan, Krishnaveni; Palaniswamy, Dhanabal S; Begum, Rahima; Islam, Md Rabiul; Tagde, Priti; Shaikh, Nusrat K; Farahim, Farha; Mondal, Tonmoy Kumar

K M, Muhasina; Ghosh, Puja; Nagappan, Krishnaveni; Palaniswamy, Dhanabal S; Begum, Rahima; Islam, Md Rabiul; Tagde, Priti; Shaikh, Nusrat K; Farahim, Farha; Mondal, Tonmoy Kumar.

Afiliación

K M M; Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Tamil Nadu, 643001, India. km.muhasina@gmail.com.
Ghosh P; Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Tamil Nadu, 643001, India.
Nagappan K; Department of Pharmaceutical Analysis, JSS College of Pharmacy, Ooty, Tamil Nadu, 643001, India.
Palaniswamy DS; Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Tamil Nadu, 643001, India. spdhanabal@jssuni.edu.in.
Begum R; Department of Microbiology, Gono Bishwabidyalay, Dhaka, Bangladesh.
Islam MR; Tennessee State University Chemistry department 3500 John A Merritt Blvd, Nashville, TN, 37209, USA.
Tagde P; PRISAL(Pharmaceutical Royal International Society), Branch Office Bhopal, Bhopal, Madhya Pradesh, 462042, India.
Shaikh NK; Department of Quality Assurance, Smt. N. M, Padalia Pharmacy College, Navapura, Ahmedabad, 382 210, Gujarat, India.
Farahim F; Department of Nursing, King Khalid University, Abha, 61413, Kingdom of Saudi Arabia.
Mondal TK; Department of Pharmacy, North South University, Dhaka, Bangladesh.

Mol Neurobiol ; 2024 Jul 05.

Article en En | MEDLINE | ID: mdl-38967904

ABSTRACT

ABSTRACT

Gut microbiota and infectious diseases affect neurological disorders, brain development, and function. Compounds generated in the gastrointestinal system by gut microbiota and infectious pathogens may mediate gut-brain interactions, which may circulate throughout the body and spread to numerous organs, including the brain. Studies shown that gut bacteria and disease-causing organisms may pass molecular signals to the brain, affecting neurological function, neurodevelopment, and neurodegenerative diseases. This article discusses microorganism-producing metabolites with neuromodulator activity, signaling routes from microbial flora to the brain, and the potential direct effects of gut bacteria and infectious pathogens on brain cells. The review also considered the neurological aspects of infectious diseases. The infectious diseases affecting neurological functions and the disease modifications have been discussed thoroughly. Recent discoveries and unique insights in this perspective need further validation. Research on the complex molecular interactions between gut bacteria, infectious pathogens, and the CNS provides valuable insights into the pathogenesis of neurodegenerative, behavioral, and psychiatric illnesses. This study may provide insights into advanced drug discovery processes for neurological disorders by considering the influence of microbial communities inside the human body.

Palabras clave

Drug discovery; Gut microbiomes; Infectious pathogens; Neurological disease; Psychiatric illness

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Neurobiol Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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