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Efficacy of pain management strategies in adults with Amyotrophic Lateral Sclerosis (ALS): A Systematic Review.
Rojas-López, Juan Camilo; Estrada-Gualdron, Pablo Isaac; Ramírez-Guerrero, Sofía; Velásquez-Cárdenas, Maria J; Redondo-Escobar, Jesús; Vargas-Arenas, Sofía; Palacios-Sánchez, Leonardo; Palacios-Espinosa, Ximena.
Afiliación
  • Rojas-López JC; Neuroscience Research Seedbed (Semineuros), Center of Neuroscience - Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  • Estrada-Gualdron PI; Neuroscience Research Seedbed (Semineuros), Center of Neuroscience - Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  • Ramírez-Guerrero S; Neuroscience Research Group (Neuros), Center of Neuroscience - Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia. sofia.ramirezg@urosario.edu.co.
  • Velásquez-Cárdenas MJ; Neuroscience Research Seedbed (Semineuros), Center of Neuroscience - Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  • Redondo-Escobar J; Neuroscience Research Seedbed (Semineuros), Center of Neuroscience - Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  • Vargas-Arenas S; Neuroscience Research Seedbed (Semineuros), Center of Neuroscience - Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  • Palacios-Sánchez L; Neuroscience Research Group (Neuros), Center of Neuroscience - Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
  • Palacios-Espinosa X; Grupo de Investigación Individuo, Familia y Sociedad Psychology Program, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Neurol Sci ; 2024 Jul 05.
Article en En | MEDLINE | ID: mdl-38967881
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle weakness. Presence of pain in ALS patients is heterogeneously reported in studies, and mostly underrepresented in symptom scales. The aim of this study is to evaluate the efficacy of pharmacological and non-pharmacological therapeutic modalities for pain management in patients with ALS. A systematic review was conducted in four databases; PubMed, Scopus, Clinicaltrials.gov, and Cochrane-Ovid. Five randomized controlled clinical trials were included regarding pharmacological and non-pharmacological pain management interventions in adult patients with confirmed diagnosis of ALS in whom pain was objectively evaluated. Risk of bias assessment was evaluated using the RoB2.0 tool. Eligible studies were reported as a descriptive analysis. This systematic review was registered with PROSPERO ID CRD42024495009. Five clinical trials regarding pain management strategies in ALS were eligible for analysis. Two out of five were non-pharmacological approaches whilst the remaining three provided pharmacological therapies. Of these, Mexiletine was efficient in terms of pain relief, particularly between 600 and 900 mg per day, whereas Mecasin showed no pain relief at both, high and low doses. Non-pharmacological therapies, such as exercise and osteopathic manual treatment also lacked efficacy in regard to pain management. Clinical trials focusing on pain management strategies for ALS patients are limited. Medical professionals, understandably focused on immediate life-threatening aspects, may inadvertently sideline the nuanced and intricate dimension of pain experienced by patients with ALS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Italia