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Comparison of Non B-Ig and B-Ig.
Xu, Xiaojun; Delves, Peter J; Huang, Jing; Shao, Wenwei; Qiu, Xiaoyan.
Afiliación
  • Xu X; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China. xiaojunxu@bjmu.edu.cn.
  • Delves PJ; Division of Infection and Immunity, Department of Immunology, UCL (University College London), London, UK.
  • Huang J; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China.
  • Shao W; Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
  • Qiu X; Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China.
Adv Exp Med Biol ; 1445: 73-88, 2024.
Article en En | MEDLINE | ID: mdl-38967751
ABSTRACT
Immunoglobulin (Ig) has been widely acknowledged to be produced solely by B-lineage cells. However, growing evidence has demonstrated the expression of Ig in an array of cancer cells, as well as normal cells including epithelial cells, epidermal cells, mesangial cells, monocytes, and neutrophils. Ig has even been found to be expressed in non-B cells at immune-privileged sites such as neurons and spermatogenic cells. Despite these non-B cell-derived Igs (non-B-Igs) sharing the same symmetric structures with conventional Igs (B-Igs), further studies have revealed unique characteristics of non-B-Ig, such as restricted variable region and aberrant glycosylation. Moreover, non-B-Ig exhibits properties of promoting malignant behaviours of cancer cells, therefore it could be utilised in the clinic as a potential therapeutic biomarker or target. The elucidation of the generation and regulation of non-B-Ig will certainly broaden our understanding of immunology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulinas Límite: Animals / Humans Idioma: En Revista: Adv Exp Med Biol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulinas Límite: Animals / Humans Idioma: En Revista: Adv Exp Med Biol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos