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Field efficacy of a novel porcine reproductive and respiratory syndrome modified-live virus vaccine with an emphasis on growth performance.
Ham, Sehyeong; Lee, Hyunjoon; Suh, Jeongmin; Kim, Chonghan; Kwon, Woo Ju; Park, Gyeong-Seo; Chae, Chanhee.
Afiliación
  • Ham S; College of Veterinary Medicine, Department of Veterinary Pathology, Seoul National University, Seoul, Republic of Korea.
  • Lee H; College of Veterinary Medicine, Department of Veterinary Pathology, Seoul National University, Seoul, Republic of Korea.
  • Suh J; College of Veterinary Medicine, Department of Veterinary Pathology, Seoul National University, Seoul, Republic of Korea.
  • Kim C; WOOGENE B&G Co., Ltd., Seoul, Republic of Korea.
  • Kwon WJ; WOOGENE B&G Co., Ltd., Seoul, Republic of Korea.
  • Park GS; WOOGENE B&G Co., Ltd., Seoul, Republic of Korea.
  • Chae C; College of Veterinary Medicine, Department of Veterinary Pathology, Seoul National University, Seoul, Republic of Korea.
Vet Med Sci ; 10(4): e1540, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38967727
ABSTRACT

BACKGROUND:

This field evaluation was designed to evaluate the efficacy of a new porcine reproductive and respiratory syndrome virus-2 (PRRSV-2) modified live virus vaccine at three independent pig farms.

METHODS:

Three farms were selected for this study based on their respiratory disease status caused by PRRSV-2 infection in post-weaning and growing pigs. Each farm housed a total of 40, 18-day-old pigs that were randomly allocated to one of two treatment groups. Pigs were administered a 1.0 mL dose of the bivalent vaccine intramuscularly at 21 days of age in accordance with the manufacturer's recommendations, whereas unvaccinated pigs were administered a single dose of phosphate buffered saline at the same age.

RESULTS:

Vaccinated groups were measured and calculated significantly (p < 0.05) higher in body weight and average daily weight gain on all three farms compared with unvaccinated groups. Vaccinated groups elicited PRRS antibodies and PRRSV-2-specific interferon-γ secreting cells, which reduced the amount of PRRSV-2 genomic copies in the blood and reduced macroscopic and microscopic lung lesions severity when compared with unvaccinated groups.

CONCLUSIONS:

The field evaluation data demonstrated that a new PRRSV-2 modified live virus vaccine was efficacious in swine herds suffering from respiratory diseases caused by PRRSV-2 infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas Atenuadas / Vacunas Virales / Virus del Síndrome Respiratorio y Reproductivo Porcino / Síndrome Respiratorio y de la Reproducción Porcina Límite: Animals Idioma: En Revista: Vet Med Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas Atenuadas / Vacunas Virales / Virus del Síndrome Respiratorio y Reproductivo Porcino / Síndrome Respiratorio y de la Reproducción Porcina Límite: Animals Idioma: En Revista: Vet Med Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido