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Neoadjuvant chemoimmunotherapy for small cell carcinoma of the esophagus: Clinical efficacy and biomarker exploration.
Wu, Junhan; Xia, Xin; Gong, Longlong; Huang, Shujie; Zheng, Hongbo; Qiao, Guibin; Tang, Yong.
Afiliación
  • Wu J; Shantou University Medical College, Shantou, China.
  • Xia X; Department of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Gong L; Department of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Huang S; Genecast Biotechnology Co. Ltd, Wuxi City, Jiangsu, China.
  • Zheng H; Department of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Qiao G; Genecast Biotechnology Co. Ltd, Wuxi City, Jiangsu, China.
  • Tang Y; Shantou University Medical College, Shantou, China.
Hum Vaccin Immunother ; 20(1): 2370085, 2024 Dec 31.
Article en En | MEDLINE | ID: mdl-38967227
ABSTRACT
Small cell carcinoma of the esophagus (SCCE) is a rare and highly malignant type of esophageal cancer with no standard treatment, facing challenges of resistance to conventional therapies. This study presents the cases of one extensive-stage and two limited-stage SCCE patients treated with chemoimmunotherapy. The two limited-stage patients underwent surgery post-treatment and experienced notable and enduring positive responses. This represents the first documented application of neoadjuvant chemoimmunotherapy in limited-stage SCCE patients. Additionally, comprehensive immunohistochemical analysis and whole exome sequencing were performed on the case patients. The findings revealed that infiltration of CD8+ T cells and PD-L1 expression in the SCCE tumor were key factors for favorable responses in SCCE patients receiving chemoimmunotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma de Células Pequeñas / Terapia Neoadyuvante / Inmunoterapia Límite: Aged / Humans / Middle aged Idioma: En Revista: Hum Vaccin Immunother Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma de Células Pequeñas / Terapia Neoadyuvante / Inmunoterapia Límite: Aged / Humans / Middle aged Idioma: En Revista: Hum Vaccin Immunother Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos