Your browser doesn't support javascript.
loading
Immunological Activity of Vaccine Systems Containing Liposomal Nanocarriers against Protozoan-Induced Diseases: A Systematic Review.
Lourenço, Francisco Dantas; Teixeira, João Victor Lima; Acacio de Moura, Gabriel; Rocha, Yasmim Mendes; Rodrigues, João Pedro Viana; Oliveira, Juliana Ramos; Pinheiro, Cristian Vicson; Nicolete, Larissa Deadame de Figueiredo; Nicolete, Roberto.
Afiliación
  • Lourenço FD; Health Science Institute, International Integration University of Afro-Brazilian Lusophony (UNILAB), Redenção - CE, Brazil.
  • Teixeira JVL; Oswaldo Cruz Foundation (FIOCRUZ CEARÁ), Eusébio - CE, Brazil.
  • Acacio de Moura G; Health Science Institute, International Integration University of Afro-Brazilian Lusophony (UNILAB), Redenção - CE, Brazil.
  • Rocha YM; Oswaldo Cruz Foundation (FIOCRUZ CEARÁ), Eusébio - CE, Brazil.
  • Rodrigues JPV; Oswaldo Cruz Foundation (FIOCRUZ CEARÁ), Eusébio - CE, Brazil.
  • Oliveira JR; Post-graduate Program in Pharmaceutical Sciences (PPGCF), Federal University of Ceará (UFC), Fortaleza-CE, Brazil.
  • Pinheiro CV; Oswaldo Cruz Foundation (FIOCRUZ CEARÁ), Eusébio - CE, Brazil.
  • Nicolete LDF; Post-graduate Program in Pharmaceutical Sciences (PPGCF), Federal University of Ceará (UFC), Fortaleza-CE, Brazil.
  • Nicolete R; Oswaldo Cruz Foundation (FIOCRUZ CEARÁ), Eusébio - CE, Brazil.
Curr Med Chem ; 2024 Jul 04.
Article en En | MEDLINE | ID: mdl-38967082
ABSTRACT

BACKGROUND:

Neglected parasitic diseases constitute a broad spectrum of clinical conditions that, in the chronic phase, lack effective therapies for the target population. The utilization of vaccines based on liposomal nanocarrier systems is emerging, thereby enhancing clinical outcomes in various comorbidities. Consequently, this study aims to assess the immunological activity induced by liposomal nanocarriers against neglected parasitic diseases.

METHODS:

For the review, the Pubmed, Embase, and Lilacs databases were used using the descriptors vaccine, parasite, and liposome. The following inclusion criteria were adopted in vivo and in vitro experimental articles. As exclusion criteria book chapters, editorials, literature reviews and duplicate articles found during the database search.

RESULTS:

A total of 226 articles were identified, from which 34 were selected for review. The primary diseases identified included Babesia bovis, Entamoeba histolytica, Leishmania braziliensis, Leishmania donovani, Leishmania major, Leishmania infantum, Plasmodium falciparum, Plasmodium chabaudi, Plasmodium chabaudi, Plasmodium yoelii, Toxoplasma gondii and Trypanosoma cruzi. An elevation in cytokines such as GM-CSF, MCP-1, INF-γ, TNF-α, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, and IL-17 was observed in the studies evaluated regarding the parasitic diseases. Furthermore, cytokines such as IL-4, IL-10, and TGF-ß were diminished with the administration of the vaccine systems in those studies.

CONCLUSION:

Therefore, the administration of liposomal nanovaccine systems can effectively ameliorate the clinical condition of patients by modulating their immunological profile.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Emiratos Árabes Unidos