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Implementation and early outcomes with Pathogen Reduced Cryoprecipitated Fibrinogen Complex.
Sethapati, V Rakesh; Pham, Tho D; Quach, Thinh; Nguyen, Anhthu; Le, Jimmy; Cai, Wei; Virk, Mrigender Singh.
Afiliación
  • Sethapati VR; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, US.
  • Pham TD; Stanford Blood Center, Palo Alto, CA, US.
  • Quach T; Department of Pathology, Stanford University School of Medicine, Stanford, CA, US.
  • Nguyen A; Department of Pathology, Stanford University School of Medicine, Stanford, CA, US.
  • Le J; Department of Pathology, Stanford University School of Medicine, Stanford, CA, US.
  • Cai W; Department of Pathology, Stanford University School of Medicine, Stanford, CA, US.
  • Virk MS; Department of Pathology, Stanford University School of Medicine, Stanford, CA, US.
Am J Clin Pathol ; 2024 Jul 05.
Article en En | MEDLINE | ID: mdl-38967047
ABSTRACT

OBJECTIVES:

Cryoprecipitated antihemophilic factor (cryo) has been used for fibrinogen replacement in actively bleeding patients, dysfibrinogenemia, and hypofibrinogenemia. Cryo has a shelf life of 4 to 6 hours after thawing and a long turnaround time in issuing the product, posing a major limitation of its use. Recently, the US Food and Drug Administration approved Pathogen Reduced Cryoprecipitated Fibrinogen Complex (INTERCEPT Fibrinogen Complex [IFC]) for the treatment of bleeding associated with fibrinogen deficiency, which can be stored at room temperature and has a shelf life of 5 days after thawing.

METHODS:

We identified locations and specific end users with high cryoprecipitate utilization and waste. We partnered with our blood supplier to use IFC in these locations. We analyzed waste and turnaround time before and after implementation.

RESULTS:

Operative locations had a waste rate that exceeded nonoperative locations (16.7% vs 3%) and were targeted for IFC implementation. IFC was added to our inventory to replace all cryo orders from adult operating rooms, and waste decreased to 2.2% in these locations. Overall waste of cryoprecipitated products across all locations was reduced from 8.8% to 2.4%. The turnaround time for cryoprecipitated products was reduced by 58% from 30.4 minutes to 14.6 minutes.

CONCLUSIONS:

There has been a substantial decrease in waste with improved turnaround time after IFC implementation. This has improved blood bank logistics, improved efficiency of patient care, and reduced costly waste.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Clin Pathol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Clin Pathol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido