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Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment.
McCurdy, Li Yan; DeVito, Elise E; Loya, Jennifer M; Nich, Charla; Zhai, Zu Wei; Kiluk, Brian D; Potenza, Marc N.
Afiliación
  • McCurdy LY; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA.
  • DeVito EE; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA.
  • Loya JM; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA.
  • Nich C; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA.
  • Zhai ZW; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA.
  • Kiluk BD; Program in Neuroscience, Middlebury College, Middlebury, VT 05753, USA.
  • Potenza MN; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA.
Drug Alcohol Depend Rep ; 11: 100246, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38966567
ABSTRACT

Background:

Few studies have investigated changes in brain structure and function associated with recovery from cocaine use disorder (CUD), and fewer still have identified brain changes associated with specific CUD treatments, which could inform treatment development and optimization.

Methods:

In this longitudinal study, T1-weighted magnetic resonance imaging scans were acquired from 41 methadone-maintained individuals with CUD (15 women) at the beginning of and after 12 weeks of outpatient treatment. As part of a larger randomized controlled trial, these participants were randomly assigned to receive (or not) computer-based training for cognitive behavioral therapy (CBT4CBT), and galantamine (or placebo).

Results:

Irrespective of treatment condition, whole-brain voxel-based morphometry analyses revealed a significant decrease in right caudate body, bilateral cerebellum, and right middle temporal gyrus gray matter volume (GMV) at post-treatment relative to the start of treatment. Subsequent region of interest analyses found that greater reductions in right caudate and bilateral cerebellar GMV were associated with higher relative and absolute levels of cocaine use during treatment, respectively. Participants who completed more CBT4CBT modules had a greater reduction in right middle temporal gyrus GMV.

Conclusions:

These results extend previous findings regarding changes in caudate and cerebellar GMV as a function of cocaine use and provide the first evidence of a change in brain structure as a function of engagement in digital CBT for addiction. These data suggest a novel potential mechanism underlying how CBT4CBT and CBT more broadly may exert therapeutic effects on substance-use-related behaviors through brain regions implicated in semantic knowledge.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Drug Alcohol Depend Rep Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Drug Alcohol Depend Rep Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos