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Genetic diversity of North African populations in the 17q21 genomic region.
Messaoudi, Mohsen; Pakstis, Andrew J; Ezzaher, Takwa; Boussetta, Sami; Ben Ammar Elgaaied, Amel; Kidd, Kenneth K; Cherni, Lotfi.
Afiliación
  • Messaoudi M; Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, University of Tunis El Manar, 2092, Tunis, Tunisia. messaoudi.prof@gmail.com.
  • Pakstis AJ; Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, USA.
  • Ezzaher T; Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, University of Tunis El Manar, 2092, Tunis, Tunisia.
  • Boussetta S; Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, University of Tunis El Manar, 2092, Tunis, Tunisia.
  • Ben Ammar Elgaaied A; Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, University of Tunis El Manar, 2092, Tunis, Tunisia.
  • Kidd KK; Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, USA.
  • Cherni L; Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences of Tunis, University of Tunis El Manar, 2092, Tunis, Tunisia.
Mamm Genome ; 35(3): 445-460, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38965090
ABSTRACT
The demographic history of human populations in North Africa has been characterized by complex migration processes that have determined the current genetic structure of these populations. We examined the autosomal markers of eight sampled populations in northern Africa (Tunisia and Libya) to explore their genetic structure and to place them in a global context. We genotyped a set of 30 autosomal single-nucleotide polymorphisms (SNPs) extending 9.5 Mb and encompassing the 17q21 inversion region. Our data include 403 individuals from Tunisia and Libya. To put our populations in the global context, we analyzed our data in comparison with other populations, including those of the 1000 Genomes Project. To evaluate the data, we conducted genetic diversity, principal component, STRUCTURE, and haplotype analyses. The analysis of genetic composition revealed the genetic heterogeneity of North African populations. The principal component and STRUCTURE analyses converged and revealed the intermediate position of North Africans between Europeans and Asians. Haplotypic analysis demonstrated that the normal (H1) and inverted (H2) polymorphisms in the chromosome 17q21 region occur in North Africa at frequencies similar to those found in European and Southwest Asian populations. The results highlight the complex demographic history of North Africa, reflecting the influence of genetic flow from Europe and the Near East that dates to the prehistoric period. These gene flows added to demographic factors (inbreeding, endogamy), natural factors (topography, Sahara), and cultural factors that play a role in the emergence of the diverse and heterogeneous genetic structures of North African populations. This study contributes to a better understanding of the complex structure of North African populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Cromosomas Humanos Par 17 / Haplotipos / Polimorfismo de Nucleótido Simple / Genética de Población Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Mamm Genome Asunto de la revista: GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Cromosomas Humanos Par 17 / Haplotipos / Polimorfismo de Nucleótido Simple / Genética de Población Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Mamm Genome Asunto de la revista: GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Estados Unidos