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Left ventricular reverse remodeling and reduction of interstitial fibrosis in patients with severe aortic stenosis who underwent transcatheter aortic valve implantation.
Wada, Teruaki; Ota, Shingo; Honda, Kentaro; Tanimoto, Takashi; Taruya, Akira; Nishi, Takahiro; Takeda, Jumpei; Hikida, Ryo; Asae, Yoshinori; Takahata, Masahiro; Ozaki, Yuichi; Kashiwagi, Manabu; Shiono, Yasutsugu; Kuroi, Akio; Yamano, Takashi; Takemoto, Kazushi; Kitabata, Hironori; Nishimura, Yoshiharu; Tanaka, Atsushi.
Afiliación
  • Wada T; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: wadat@wakayama-med.ac.jp.
  • Ota S; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Honda K; Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan.
  • Tanimoto T; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Taruya A; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Nishi T; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Takeda J; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Hikida R; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Asae Y; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Takahata M; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Ozaki Y; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Kashiwagi M; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Shiono Y; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Kuroi A; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Yamano T; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Takemoto K; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Kitabata H; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
  • Nishimura Y; Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan.
  • Tanaka A; Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
Cardiovasc Revasc Med ; 2024 Jun 29.
Article en En | MEDLINE | ID: mdl-38965018
ABSTRACT

BACKGROUND:

Left ventricular (LV) structural and functional changes have been reported in patients with aortic stenosis (AS) who have undergone transcatheter aortic valve implantation (TAVI); however, the relationship between change in LV structure and systolic function and tissue characteristics assessed via cardiovascular magnetic resonance imaging (CMRI) post-TAVI has been not fully elucidated. This study aimed to investigate this relationship in patients with severe AS who underwent TAVI and CMRI.

METHODS:

In this retrospective study, 65 patients who underwent TAVI and CMRI at the 6-month follow-up were analyzed. The relationship between percent changes in LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), LV ejection fraction (LVEF), and LV mass (LVM) (⊿LVEDV, ⊿LVESV, ⊿LVEF, and ⊿LVM) and those in the native T1 value (⊿native T1) was analyzed using a correlation analysis. Moreover, extracellular volume fraction (ECV) value changes were analyzed.

RESULTS:

The ⊿native T1 significantly decreased from 1292.8 (1269.9-1318.4) ms at pre-TAVI to 1282.3 (1262.6-1310.2) ms at the 6-month follow-up (P = 0.022). A significant positive correlation between ⊿LVEDV, ⊿LVESV, and ⊿LVM and ⊿native T1 (r = 0.351, P = 0.004; r = 0.339, P = 0.006; r = 0.261, P = 0.035, respectively) and a tendency toward a negative correlation between ⊿LVEF and ⊿native T1 (r = -0.237, P = 0.058) were observed. The ECV value increased significantly from 26.7 % (25.3-28.3) to 28.2 % (25.7-30.5) (P = 0.002).

CONCLUSIONS:

The decrease in native T1 might be associated with LV reverse remodeling. Evaluating structural and functional changes using CMRI may be useful for patient management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cardiovasc Revasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cardiovasc Revasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos