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Oleanane-type saponins from Lysimachia laxa Baudo and their anti-bacterial activities.
Luyen, Nguyen Thi; Dat, Nguyen Tien; Giang, Do Hoang; Thuy, Nguyen Thi Kim; Tai, Bui Huu; Huong, Phan Thi Thanh; Quynh, Le Thi Phuong; Thuy, Duong Thi; Park, SeonJu; Nhiem, Nguyen Xuan.
Afiliación
  • Luyen NT; Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Dat NT; Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Giang DH; Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Thuy NTK; Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam.
  • Tai BH; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
  • Huong PTT; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
  • Quynh LTP; Institute of Natural Product Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
  • Thuy DT; Institute of Science and Technology for Energy and Environment, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
  • Park S; Metropolitan Seoul Center, Korea Basic Science Institute, Seoul 03579, Republic of Korea.
  • Nhiem NX; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Biosci Biotechnol Biochem ; 2024 Jul 04.
Article en En | MEDLINE | ID: mdl-38964835
ABSTRACT
Seven new oleanane-type triterpene saponins, lysimaponins A-G, were isolated from aerial parts of Lysimachia laxa Baudo. Their chemical structures have been elucidated by analysis of spectroscopic and chemical methods. All compounds were evaluated for their anti-bacterial effects against Microcystis aeruginosa, Vibrio parahaemolyticus, V. harveyi, V. vulinificus, V. cholerae, and V. alginolyticus. All compounds showed potent anti-bacterial activities against the cyanobacteria M. aeruginosa with IC50 values ranging from 14.4 ± 1.2 to 35.3 ± 2.2 µg/mL. Compounds 1, 2, 4-7 inhibited V. parahaemolyticus with MIC values ranging from 64 to 256 µg/mL. The results suggested that saponins from L. laxa could be potential anti-cyanobacteria agents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido