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Low-viscosity hydroxypropyl methylcellulose obtained by electron beam irradiation and its performance in spray drying.
Cheng, Hong; Wang, Youjie; Hong, Yanlong; Wu, Fei; Shen, Lan; Lin, Xiao.
Afiliación
  • Cheng H; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
  • Wang Y; Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address: shutcmyo@163.com.
  • Hong Y; Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
  • Wu F; Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
  • Shen L; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
  • Lin X; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address: duotang@163.com.
Int J Biol Macromol ; 275(Pt 1): 133626, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38964691
ABSTRACT
Low-viscosity hydroxypropyl methylcellulose (HPMC) was obtained by electron beam irradiation, and its use as an excipient for improving the properties of spray dried pharmaceutical powders was investigated. The minimum molecular weight of HPMC which could maintain the capacity of encapsulation and powder modification was explored. As the irradiation dose was increased from 10 to 200 kGy, the molecular weight and viscosity of HPMC decreased linearly. However, its main structure and degrees of methoxy and hydroxypropyl substitution were not significantly affected. The irradiated HPMC could encapsulate particles during spray drying and, thus, modify powder properties. Furthermore, the water content of spray-dried powders with irradiated HPMC was lower than that with parent HPMC. After the spray-dried powder with irradiated HPMC was prepared into granules, their dissolution rate was also faster. However, in order to achieve high encapsulation, the molecular weight of HPMC should be ensured to be above 7.5 kDa. The designated low-viscosity HPMC obtained by electron beam irradiation is a suitable powder-modification material for use in spray drying, and it shows promise as a superior excipient in medicine, food, paint industries, among others.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electrones / Derivados de la Hipromelosa / Secado por Pulverización / Peso Molecular Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electrones / Derivados de la Hipromelosa / Secado por Pulverización / Peso Molecular Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos