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Genetic and recombination heterogeneity of canine bufaviruses detected in diarrheal dogs in China.
Ji, Jun; Cui, Hao; Zhang, Zhibin; Liu, Qiang; Xu, Xin; Zuo, Kejing; Bi, Yingzuo; Yao, Lunguang.
Afiliación
  • Ji J; Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering, and Technology Center of Health Products for Livestock and Poultry, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Nanyang Normal University, Nanyang
  • Cui H; Laboratory of Animal Center, Chifeng Municipal Hospital, Chifeng, Inner Mongolia 024000, PR China.
  • Zhang Z; Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering, and Technology Center of Health Products for Livestock and Poultry, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Nanyang Normal University, Nanyang
  • Liu Q; Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering, and Technology Center of Health Products for Livestock and Poultry, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Nanyang Normal University, Nanyang
  • Xu X; Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering, and Technology Center of Health Products for Livestock and Poultry, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Nanyang Normal University, Nanyang
  • Zuo K; Guangzhou Zoo and Guangzhou Wildlife Research Center, Guangzhou 510070, PR China. Electronic address: zuo_5502077@163.com.
  • Bi Y; South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, South China Agricultural University, Guangzhou 510642, PR China.
  • Yao L; Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering, and Technology Center of Health Products for Livestock and Poultry, Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Nanyang Normal University, Nanyang
Vet J ; 306: 106192, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38964602
ABSTRACT
Bufavirus (BuV) was first identified in feces from children with acute diarrhea, and a genetically related Canine bufavirus (CBuV) was first reported in Italy in 2018. In this study, through the investigation of CBuV in 622 anal swabs from dogs with diarrhea symptoms collected from various provinces in northern, central and eastern China during 2018-2022, 14 samples were detected to be positive. And 5 samples were from dogs co-infected with other canine diarrhea related viruses, which consist of CPV-2, CDV and CCoV. The complete genome sequences (4219 nt) of the fourteen strains were amplified and sequenced. Through comparative analysis with 51 reference BuV strains, six strains might recombinate from the CBuV strains (HUN/2012/22, CaBuV/9AS/2005/ITA and CaBuV/35/2016/ITA) in Hungary and Italy as the parents, and two genetic recombination events from various parents were predicted to occur on the BUV-422 strain. Combined analyzing the phylogenetic tree and sequence alignment, it was found that these CBuVs are highly conserved in the nonstructural protein NS1, but indeed various amino acid mutation sites in the capsid protein VP2, and even some amino acid sites coincide with putative protein plastic regions and potential epitopes. The BUV-422 and BUV-512 strains show sequential mutation sites identical to the divergent strains of CaBuV/9AS/2005/ITA and CaBuV/35/2016/ITA. This study would enrich the molecular data of CBuV in China and provide essential reference for the epidemiological research and vaccine development of CBuV in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Recombinación Genética / Infecciones por Parvoviridae / Diarrea / Enfermedades de los Perros Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Vet J Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Recombinación Genética / Infecciones por Parvoviridae / Diarrea / Enfermedades de los Perros Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Vet J Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido