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The pollutant perfluorohexane sulfonate (PFHxS) reduces serum thyroxine but does not alter thyroid action in the postnatal rat brain.
O'Shaughnessy, Katherine L; Bell, Kiersten S; Sasser, Aubrey L; Gilbert, Mary E; Riutta, Cal; Ford, Jermaine L; McCord, James; Wood, Carmen R.
Afiliación
  • O'Shaughnessy KL; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA. Electronic address: oshaughnessy.katie@epa.gov.
  • Bell KS; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA; Oak Ridge Institute for Science and Education, Oak Ridge 37831, TN, USA.
  • Sasser AL; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA; Oak Ridge Institute for Science and Education, Oak Ridge 37831, TN, USA.
  • Gilbert ME; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA.
  • Riutta C; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA; Oak Ridge Institute for Science and Education, Oak Ridge 37831, TN, USA.
  • Ford JL; Chemical Characterization and Exposure Division, Center for Computational Toxicology and Exposure, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA.
  • McCord J; Watershed and Ecosystem Characterization Division, Center for Environmental Measurement and Modeling, United States Environmental Protection Agency Research Triangle Park, NC 27709, USA.
  • Wood CR; Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, NC 27709, USA.
Environ Int ; 190: 108838, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38963985
ABSTRACT
Known as "forever chemicals", per- and polyfluoroalkyl substances (PFAS) are synthetic compounds used in consumer goods but pose significant public health concerns, including disruption of the thyroid system. As thyroid hormones (THs) are required for normal brain development, PFAS may also be developmental neurotoxicants. However, this is not well understood. Here we examine the endocrine and neurodevelopmental consequences of perfluorohexane sulfonate (PFHxS) exposure in pregnant, lactating, and developing rats, and compare its effects to an anti-thyroid pharmaceutical (propylthiouracil, PTU) that induces thyroid-mediated developmental neurotoxicity. We show that PFHxS dramatically reduces maternal serum thyroxine (T4), nearly equivalently to PTU (-55 and -51%, respectively). However, only PTU increases thyroid stimulating hormone. The lactational transfer of PFHxS is significant and reduces pup serum T4 across the postnatal period. Surprisingly, brain THs are only minimally decreased by PFHxS, whereas PTU drastically diminishes them. Evaluation of brain TH action by phenotyping, RNA-Sequencing, and quantification of radial glia cell morphology supports that PTU interrupts TH signaling while PFHxS has limited to no effect. These data show that PFHxS induces abnormal serum TH profiles; however, there were no indications of hypothyroidism in the postnatal brain. We suggest the stark differences between the neurodevelopmental effects of PFHxS and a typical antithyroid agent may be due to its interaction with TH distributing proteins like transthyretin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Sulfónicos / Glándula Tiroides / Tiroxina / Encéfalo / Fluorocarburos Límite: Animals / Pregnancy Idioma: En Revista: Environ Int Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Sulfónicos / Glándula Tiroides / Tiroxina / Encéfalo / Fluorocarburos Límite: Animals / Pregnancy Idioma: En Revista: Environ Int Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos