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Impact of Plateletpheresis on the Hemoglobin, Hematocrit, and Total Red Blood Cell Count: An Updated Meta-Analysis.
Ashok, Chanchal; Mahto, Sunil; Kumari, Sushma; Kumar, Amit; Prasad, Manoj; Mahajan, Mayank; Chaudhuri, Partha Kumar.
Afiliación
  • Ashok C; Pathology, Rajendra Institute of Medical Sciences, Ranchi, IND.
  • Mahto S; Pathology, Rajendra Institute of Medical Sciences, Ranchi, IND.
  • Kumari S; Blood Bank, Rajendra Institute of Medical Sciences, Ranchi, IND.
  • Kumar A; Laboratory Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
  • Deepankar; Ophthalmology, Rajendra Institute of Medical Sciences, Ranchi, IND.
  • Vidyapati; Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
  • Prasad M; Internal Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
  • Mahajan M; Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
  • Chaudhuri PK; Paediatrics, Rajendra Institute of Medical Sciences, Ranchi, IND.
Cureus ; 16(6): e61510, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38962593
ABSTRACT
Plateletpheresis has become a pivotal part of transfusion medicine. With the increasing demand for plateletpheresis, donor safety is an area of concern because plateletpheresis alters donor hematological parameters. For a better understanding of plateletpheresis, a systemic review is needed to study more evidence-based aspects of plateletpheresis. Electronic databases PubMed, Google Scholar, and Cochrane Library were used to find articles from January 1, 1980, to May 23, 2024. The random effect model was used to meta-analyze the effect of plateletpheresis on hematocrit, hemoglobin, and red blood cell (RBC) count. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed. A total of 24 studies were found; the effect of plateletpheresis on hemoglobin, hematocrit, and RBC count was studied in the following respective numbers of donors 3,374, 3,374, and 690. A decrease of hemoglobin, hematocrit, and RBC count was observed after plateletpheresis having a weighted mean difference (WMD) of 0.50 (95%CI = -0.72 to -0.27), WMD of -1.36 (95%CI = -2.05 to -0.66), and WMD of -0.18 (95%CI = -0.23 to -0.12), respectively. Plateletpheresis shows a decrease in the value of hematological parameters such as hemoglobin, hematocrit, and erythrocyte count due to blood loss in the kits employed in the procedure; cell lysis was also seen because of exposure of erythrocytes to stress or change in osmotic pressure. Thus, strict criteria for donation must be developed for better safety of the donors. Improved automated cell separators for plateletpheresis should be made available in blood banks to ensure good quality hematologic products. Our findings suggest that the duration of the procedure should be decreased.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos