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Competitive inhibition and mutualistic growth in co-infections: deciphering Staphylococcus aureus-Acinetobacter baumannii interaction dynamics.
Timme, Sandra; Wendler, Sindy; Klassert, Tilman E; Saraiva, Joao Pedro; da Rocha, Ulisses Nunes; Wittchen, Manuel; Schramm, Sareda; Ehricht, Ralf; Monecke, Stefan; Edel, Birgit; Rödel, Jürgen; Löffler, Bettina; Ramirez, Maria Soledad; Slevogt, Hortense; Figge, Marc Thilo; Tuchscherr, Lorena.
Afiliación
  • Timme S; Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Friedrich Schiller University Jena, Leibniz Centre for Photonics in Infection Research (LPI), D-07743 Jena, Germany.
  • Wendler S; Institute of Medical Microbiology, Jena University Hospital, D-07740 Jena, Germany.
  • Klassert TE; Respiratory Infection Dynamics, Helmholtz Centre for Infection Research - HZI, D-38124 Braunschweig, Germany.
  • Saraiva JP; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, German Center for Lung Research (DZL), BREATH, D-30625 Hannover, Germany.
  • da Rocha UN; Department of Environmental Microbiology, Helmholtz Centre for Environmental Research-UFZ, D-04318 Leipzig, Germany.
  • Wittchen M; Department of Environmental Microbiology, Helmholtz Centre for Environmental Research-UFZ, D-04318 Leipzig, Germany.
  • Schramm S; Center for Biotechnology, Bielefeld University, D-33501 Bielefeld, Germany.
  • Ehricht R; Department of Biological Science, Center for Applied Biotechnology Studies, California State University, 800 N State College Blvd, Fullerton, CA 92831, United States.
  • Monecke S; Leibniz Institute of Photonic Technology, Leibniz Centre for Photonics in Infection Research (LPI), D-07745 Jena, Germany.
  • Edel B; Institute of Physical Chemistry, Friedrich Schiller University Jena, Leibniz Centre for Photonics in Infection Research (LPI) , D-07743 Jena, Germany.
  • Rödel J; Leibniz Institute of Photonic Technology, Leibniz Centre for Photonics in Infection Research (LPI), D-07745 Jena, Germany.
  • Löffler B; Institute for Medical Microbiology and Virology, Dresden University Hospital, Dresden, Germany.
  • Ramirez MS; Institute of Medical Microbiology, Jena University Hospital, D-07740 Jena, Germany.
  • Slevogt H; Institute of Medical Microbiology, Jena University Hospital, D-07740 Jena, Germany.
  • Figge MT; Institute of Medical Microbiology, Jena University Hospital, D-07740 Jena, Germany.
  • Tuchscherr L; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, D-07743 Jena, Germany.
ISME Commun ; 4(1): ycae077, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38962494
ABSTRACT
Staphylococcus aureus (Sa) and Acinetobacter baumannii (Ab) are frequently co-isolated from polymicrobial infections that are severe and refractory to therapy. Here, we apply a combination of wet-lab experiments and in silico modeling to unveil the intricate nature of the Ab/Sa interaction using both, representative laboratory strains and strains co-isolated from clinical samples. This comprehensive methodology allowed uncovering Sa's capability to exert a partial interference on Ab by the expression of phenol-soluble modulins. In addition, we observed a cross-feeding mechanism by which Sa supports the growth of Ab by providing acetoin as an alternative carbon source. This study is the first to dissect the Ab/Sa interaction dynamics wherein competitive and cooperative strategies can intertwine. Through our findings, we illuminate the ecological mechanisms supporting their coexistence in the context of polymicrobial infections. Our research not only enriches our understanding but also opens doors to potential therapeutic avenues in managing these challenging infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ISME Commun Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ISME Commun Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido