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Social impact of brain fog and analysis of risk factors: Long COVID in Japanese population.
Shigematsu, Lisa; Kimura, Ryusei; Terai, Hideki; Mimura, Yu; Ito, Daisuke; Bun, Shogyoku; Namkoong, Ho; Asakura, Takanori; Chubachi, Shotaro; Masaki, Katsunori; Ohgino, Keiko; Miyata, Jun; Kawada, Ichiro; Ishii, Makoto; Takemura, Ryo; Ueda, Soichiro; Yoshiyama, Takashi; Kokuto, Hiroyuki; Kusumoto, Tatsuya; Oashi, Ayano; Miyawaki, Masayoshi; Saito, Fumitake; Tani, Tetsuo; Ishioka, Kota; Takahashi, Saeko; Nakamura, Morio; Sato, Yasunori; Fukunaga, Koichi.
Afiliación
  • Shigematsu L; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Kimura R; Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
  • Terai H; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Mimura Y; Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan.
  • Ito D; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Bun S; Department of Physiology/Memory Center, Keio University School of Medicine, Tokyo, Japan.
  • Namkoong H; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Asakura T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Chubachi S; Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
  • Masaki K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Ohgino K; Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Tokyo, Japan.
  • Miyata J; Department of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
  • Kawada I; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Ishii M; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Takemura R; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Ueda S; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Yoshiyama T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Kokuto H; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kusumoto T; Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
  • Oashi A; Department of Internal Medicine, Saitama Medical Center, Saitama, Japan.
  • Miyawaki M; Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
  • Saito F; Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
  • Tani T; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Ishioka K; Department of Pulmonary Medicine, Eiju General Hospital, Tokyo, Japan.
  • Takahashi S; Department of Pulmonary Medicine, Eiju General Hospital, Tokyo, Japan.
  • Nakamura M; Department of Pulmonary Medicine, Eiju General Hospital, Tokyo, Japan.
  • Sato Y; Department of Pulmonary Medicine, Eiju General Hospital, Tokyo, Japan.
  • Fukunaga K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ann Clin Transl Neurol ; 11(8): 2188-2200, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38961833
ABSTRACT

OBJECTIVE:

To reveal the clinical features and assess risk factors linked to brain fog and its societal implications, including labor productivity, providing valuable insights for the future care of individuals who have experienced coronavirus disease 2019 (COVID-19).

METHODS:

We analyzed a comprehensive cohort dataset comprising 1,009 patients with COVID-19 admitted to Japanese hospitals. To assess brain fog, we analyzed patients who responded to a questionnaire indicating symptoms such as memory impairment and poor concentration.

RESULTS:

The prevalence of brain fog symptoms decreased 3 months posthospitalization but remained stable up to 12 months. Neurological symptoms such as taste and smell disorders and numbness at hospitalization correlated with a higher frequency of identifying brain fog as a long COVID manifestation. Our findings indicated that advanced age, female sex, a high body mass index, oxygen required during hospitalization, chronic obstructive pulmonary disease, asthma, and elevated C-reactive protein and elevated D-dimer levels were risk factors in patients exhibiting brain fog. Additionally, we demonstrated the negative impact of brain fog on labor productivity by presenteeism scores. INTERPRETATIONS This study clarified the clinical characteristics of patients experiencing brain fog as a long COVID manifestation, specifically emphasizing neurological symptoms during hospitalization and their correlation with brain fog. Additionally, the study identified associated risk factors for its onset and revealed that the emergence of brain fog was linked to a decline in labor productivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fatiga Mental / COVID-19 Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Ann Clin Transl Neurol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fatiga Mental / COVID-19 Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Ann Clin Transl Neurol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos